Publications by authors named "M-L Ayoub"
Article Synopsis
- The COVID-19 pandemic disrupted access to surveillance and treatments for hepatocellular carcinoma (HCC), leading to underdiagnosis and variable treatment outcomes in the U.S.
- A study analyzing HCC incidence and mortality from 2001 to 2020 found a 12.2% decrease in the age-adjusted incidence rate in 2020 compared to 2019, especially among Black and Hispanic individuals.
- Despite the decrease in diagnosed cases, short-term overall survival and mortality rates for HCC remained stable during this period, highlighting a need for further research on long-term effects.
Resistance to apoptosis in acute myeloid leukemia (AML) cells causes refractory or relapsed disease, associated with dismal clinical outcomes. Ferroptosis, a mode of non-apoptotic cell death triggered by iron-dependent lipid peroxidation, has been investigated as potential therapeutic modality against therapy-resistant cancers, but our knowledge of its role in AML is limited. We investigated ferroptosis in AML cells and identified its mitochondrial regulation as a therapeutic vulnerability.
View Article and Find Full Text PDFThe World Health Organization (WHO) classification of hematolymphoid tumors and the International Consensus Classification (ICC) of 2022 introduced major changes to the definition of chronic myelomonocytic leukemia (CMML). To assess its qualitative and quantitative implications for patient care, we started with 3311 established CMML cases (according to WHO 2017 criteria) and included 2130 oligomonocytosis cases fulfilling the new CMML diagnostic criteria. Applying both 2022 classification systems, 356 and 241 of oligomonocytosis cases were newly classified as myelodysplastic (MD)-CMML (WHO and ICC 2022, respectively), most of which were diagnosed as myelodysplastic syndrome (MDS) according to the WHO 2017 classification.
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