Preparation and Characteristics of Porous Mullite Ceramics by 3D Printing and In-Situ Synthesis.

In-situ porous mullite ceramics with varying pore size and porosity were fabricated using 3D printing. The pore size was controlled by adjusting the size of polymethyl methacrylate (PMMA) microspheres. The effect of sintering temperature on phase evolution was also examined.

Thermally Conductive Naphthalene Epoxy Resin by Tailoring Flexible Chain Length and Liquid Crystal Structure.

Epoxy resin with high thermal conductivity (λ) are widely used in electronic packaging, bonding, and coating. However, those with high intrinsic λ, typically synthesized using biphenyl or aromatic rings extended by ester linkages as the mesogenic unit, often exhibit high liquid crystal transition temperatures and poor processability. In this study, a series of naphthalene-based liquid crystal epoxy monomers (LCE) were synthesized, using naphthalene as the mesogenic unit and modifying the flexible chain length on both sides.

Phenolic Modified SiO Aerogel as a Hybrid Thermal Insulation Systems.

SiO aerogel is a good thermal insulation material, but its porous nanostructure makes it brittle and has a poor mechanical property. SiO aerogel with a good elastic property was prepared by combining methyltrimethoxysilane (MTMS) and hexadecyltrimethoxysilane to form a composite organic silane precursor. However, its mechanical properties were not significantly improved.

Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial.

First-line nivolumab-plus-chemotherapy demonstrated superior overall survival (OS) and progression-free survival versus chemotherapy for advanced gastroesophageal adenocarcinoma with programmed death ligand 1 combined positive score ≥ 5, meeting both primary end points of the randomized phase 3 CheckMate 649 trial. Nivolumab-plus-ipilimumab provided durable responses and higher survival rates versus chemotherapy; however, the prespecified OS significance boundary was not met. To identify biomarkers predictive of differential efficacy outcomes, post hoc exploratory analyses were performed using whole-exome sequencing and RNA sequencing.

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.

Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B.

Sodium alginate aerogel derived SiC@Co-C 3D network enhances electromagnetic wave absorption and thermal conductivity of PDMS based composite.

Interface packaging materials with both electromagnetic wave absorption and high thermal conductivity remains a research hotspot in modern electronics industry and aerospace field. In this paper, the cobalt alginate aerogel derived from biomass sodium alginate was carbothermal reduced to obtain a three-dimensional skeleton structure composed of zero-dimensional Co metal particles, one-dimensional silicon carbide (SiC) whiskers and biomass derived carbon (C). The dielectric-electromagnetic effect of the filler network makes the obtained polydimethylsiloxane (PDMS) based composite (PDMS/SiC@Co-C) exhibits good electromagnetic wave absorption performance, with the lowest reflection loss (RL) value can reach -40.

Dual chemical crosslinking strategy to fabricate lightweight, flame-retardant, high-modulus and hydrophobic cellulose cryogel.

Cellulose cryogel shows great application potential as a thermal insulation material because of its eco-friendliness, lightweight, high porosity and highly-efficient thermal insulation property. However, the high flammability and hydrophilicity have become bottlenecks to restrict its application in the thermal insulation field. Herein, we synthesized an amylose derivative with ammonium phosphate groups (AM), and reported a dual chemical crosslinking strategy to fabricate lightweight, flame-retardant, high-modulus and hydrophobic cellulose cryogel with AM and methyltrimethoxysilane (MTMS) via baking-crosslinking and chemical vapor deposition techniques.

The Impact of Anhedonia on the Disease Burden of Major Depressive Disorder in the Asia-Pacific Region: A Cross-Sectional Real-World Study.

Aim: Anhedonia is a key symptom of major depressive disorder (MDD), however, its burden in patients with MDD is not well understood. We aimed to assess the impact of anhedonia on health-related quality of life (HRQoL), health-care resource utilization (HRU), and work productivity in subjects with MDD and anhedonia (MDD-ANH) compared to subjects with MDD without ANH (MDD non-ANH).

Methods: A cross-sectional web-based survey was conducted across six countries/territories.

Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth.

Crossing the blood-brain barrier (BBB) and reaching intracranial tumours is a clinical challenge for current targeted interventions including antibody-based therapies, contributing to poor patient outcomes. Increased cell surface density of human epidermal growth factor receptor 3 (HER3) is associated with a growing number of metastatic tumour types and is observed on tumour cells that acquire resistance to a growing number of clinical targeted therapies. Here we describe the evaluation of HER3-homing nanobiological particles (nanobioparticles (NBPs)) on such tumours in preclinical models and our discovery that systemic NBPs could be found in the brain even in the absence of such tumours.

A waterproof and breathable cellulosic composite with thermal management inspired by penguins.

Temperature is paramount for human body, contributing to a growing demand for enhanced thermal comfort in wearable textiles. However, it is still a major challenge to prepare multifunctional thermal comfort materials with integrated insulation strategies. The Antarctic penguin uses its feathers to maintain body temperature by three different functional layers, namely photothermal conversion layer, thermal insulation layer and infrared reflective layer.

Three-dimensional perchlorate-based alkali metal hybrid perovskite molecular ferroelastic crystals.

Hybrid perovskites possessing structural diversity and solution processability have been extensively studied in numerous application scenarios and have attracted significant interest in the design of high-performance molecular ferroelectric and ferroelastic materials. However, reports on the construction of three-dimensional (3D) perchlorate-based alkali metal hybrid perovskite molecular ferroelastics are scarce. Herein, dual-site substitution was implemented on the 3D non-perovskite network (MDABCO)K(ClO) (MDABCO = -methyl-'-diazabicyclo[2.

Multiscale Porous Heat Insulation Polypropylene Foam with High Infrared Absorption Performance.

Polypropylene (PP) foam is a potential high-temperature insulating porous material with high mechanical properties and service temperature. However, the development of insulating and multifunctional foams based on PP still faces challenges. In this study, grafting by ultraviolet (UV) radiation was successfully used to introduce ester-based groups into PP molecular chains.

Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma.

In a phase 1 clinical trial open to accrual from 2004 to 2009, we treated children with neuroblastoma with Epstein-Barr virus (EBV)-specific T lymphocytes and CD3-activated T cells-each expressing chimeric antigen receptors (CARs) targeting GD2 but without an embedded co-stimulatory sequence (first-generation CARs). These CARs incorporated barcoded sequences to track each infused population. We previously reported outcomes up to 5 years and now report long-term outcomes up to 18 years.

Predicting visual field global and local parameters from OCT measurements using explainable machine learning.

Glaucoma is characterised by progressive vision loss due to retinal ganglion cell deterioration, leading to gradual visual field (VF) impairment. The standard VF test may be impractical in some cases, where optical coherence tomography (OCT) can offer predictive insights into VF for multimodal diagnoses. However, predicting VF measures from OCT data remains challenging.

Eco-friendly and efficient flame retardant rigid polyurethane foam reinforced with lignin and silica aerogel.

With the continuous improvement of living standards, the development of eco-friendly rigid polyurethane foam (RPUF) materials with excellent flame retardancy, thermal insulation, and outstanding mechanical strength has become an urgent challenge. This study presented an innovative strategy using lignin as a mechanical reinforcement and flame-retardant synergist, combined with DMMP and EG as highly efficient flame retardants. Furthermore, the incorporation of a silica aerogel coating via surface post-treatment significantly enhanced the flame retardancy of the composite.

A new strategy to achieve high-performance thermally insulating biodegradable foams enabled by polylactide and epoxidized soybean oil.

As the thermal energy dissipation and environmental pollution intensify, light-weight and biodegradable thermal insulation materials have gained significant attention. Poly(butylene adipate-co-terephthalate) (PBAT) foams, renowned for their exceptional biodegradability and thermal insulation properties, could serve as a promising material for thermal insulation. Regrettably, the insufficient foamability and inherent shrinkage behavior of PBAT foams continue to be major obstacle in developing high-performance flexible PBAT foams.

Thermal Insulating and Mechanically Strong Polyimide Aerogel Composites Reinforced by Polyhedral Oligomeric Silsesquioxane-Grafted Carbon Nanotubes.

In the ship industry, developing thermal insulation materials with exceptional high-temperature resistance, structural stability and light weight is essential. Herein, polyimide (PI) composite aerogels were synthesized. Carbon nanotubes (CNTs) introduced cross-linking structures within the aerogel matrix, effectively reducing shrinkage and forming micrometer-scale pores.

Bleeding Risks With Non-Vitamin K Oral Anticoagulants Versus Single Antiplatelet Therapy : A Systematic Review and Meta-analysis of Randomized Trials.

Background: In several settings, therapeutic-dose non-vitamin K oral anticoagulants (NOACs) are superior to aspirin for the prevention of arterial and venous thromboembolism.

Purpose: To estimate differences in bleeding risks between NOACs and single antiplatelet therapy.

Data Sources: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.

Light Weight Organic Composites with High Thermal Management Capability.

With the advancement of science and technology, effectively addressing the issue of heat dissipation in electronic equipment has become a key research topic. Polymers have attracted attention due to their low price, excellent flexibility, and lightweight characteristics, but thermal conductivity has a limitation. In this work, aiming for all-polymer composites with lightweight and high thermal conductivity, poly(p-phenylene benzobisoxazole) (PBO) fibers were used to construct a long-range ordered heat transfer path in the organosilicon matrix, and an all-organic composite material with a low density of 1.

Chitosan cryogels incorporated with phytic acid-modified UiO-66-NH for enhanced flame-retardant performance.

In this work, chitosan (CS) was used as the skeleton to synthesize flame-retardant composite cryogels. Phytic acid (PA)-modified Zr-based metal-organic framework (PA-UiO-66-NH) was integrated into the CS network to enhance flame retardant performance. The vertical combustion test (UL-94) grade was V-0, and the limiting oxygen index (LOI) value reached 39 % when the flame retardant (PA-UiO-66-NH) addition content was 15 %.

Measurement of CP Asymmetries in B^{0}→K_{S}^{0}π^{0}γ Decays at Belle II.

We report measurements of time-dependent CP asymmetries in B^{0}→K_{S}^{0}π^{0}γ decays based on a data sample of (388±6)×10^{6}  BB[over ¯] events collected at the ϒ(4S) resonance with the Belle II detector. The Belle II experiment operates at the SuperKEKB asymmetric-energy e^{+}e^{-} collider. We measure decay-time distributions to determine CP -violating parameters S and C.

Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS trial.

Frontline daratumumab-based triplet and quadruplet standard-of-care regimens have demonstrated improved survival outcomes in newly diagnosed multiple myeloma (NDMM). For patients with transplant-ineligible NDMM, triplet therapy with either daratumumab plus lenalidomide and dexamethasone (D-Rd) or bortezomib, lenalidomide and dexamethasone (VRd) is the current standard of care. This phase 3 trial evaluated subcutaneous daratumumab plus VRd (D-VRd) in patients with transplant-ineligible NDMM or for whom transplant was not planned as the initial therapy (transplant deferred).

MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies.

The COVID-19 pandemic underscores the need to prepare for future emerging coronavriuses (CoVs) by understanding the principles behind effective CoV vaccine design such as protective immunity and antibody responses. To study which epitopes and subdomains contribute to protection, we utilized the prefusion-stabilized spike protein of MERS-CoV, MERS S-2P, as a vaccine immunogen. Vaccination with MERS S-2P elicited both receptor-binding domain (RBD)- and non-RBD-specific antibodies, including N-terminal domain (NTD)-specific G2-and CDC2-A2-like antibodies.

Ten-Year Trends in Last Known Well to Arrival Time in Acute Ischemic Stroke Patients: 2014 to 2023.

Background: Many national initiatives focus on promoting early hospital arrival of patients with acute ischemic stroke (AIS) because treatment effectiveness is time-dependent. However, several studies reported time-delays in hospital arrival, especially during the COVID-19 pandemic. Our purpose was to evaluate the 10-year trends in last known well to arrival (LKWA) time and assess disparities in patients with AIS.