Publications by authors named "M-J Stowe"
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia.
CPT Pharmacometrics Syst Pharmacol
March 2024
Model-informed precision dosing using virtual twins (MIPD-VTs) is an emerging strategy to predict target drug concentrations in clinical practice. Using a high virtualization MIPD-VT approach (Simcyp version 21), we predicted the steady-state clozapine concentration and clozapine dosage range to achieve a target concentration of 350 to 600 ng/mL in hospitalized patients with treatment-resistant schizophrenia (N = 11). We confirmed that high virtualization MIPD-VT can reasonably predict clozapine concentrations in individual patients with a coefficient of determination (R ) ranging between 0.
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- Researchers wanted to see if a medicine called valproate could help protect the brain after an injury called subarachnoid hemorrhage (SAH) in rats.
- They tested valproate on rats and found that it reduced the growth of brain damage when they induced something called spreading depolarizations (SDs).
- The study concluded that valproate might help limit brain injury after SAH, but more research is needed to understand how it works.