Publications by authors named "M-I Richard"
Article Synopsis
- - A global study conducted from January to April 2023 assessed pruritus (itching) prevalence among 50,552 individuals across 20 countries, revealing an overall prevalence of 39.8%.
- - The study found that older adults (65+) had the highest prevalence at 43.3%, with women experiencing pruritus more frequently (40.7%) than men (38.9%).
- - Geographic differences showed higher pruritus rates in Africa (45.7%) compared to North America (41.2%) and lower rates in Europe (35.9%) and Australia (38.4%), with no notable ethnic differences in prevalence.
Rationale & Objective: In this pilot study, we hypothesized that autosomal dominant polycystic kidney disease (ADPKD) is characterized by impaired kidney oxidative metabolism that associates with kidney size and cyst burden.
Study Design: Cross-sectional study.
Setting & Participants: Twenty adults with ADPKD (age, 31±6 years; 65% women; body mass index [BMI], 26.
Article Synopsis
- A phase 1/1b study is being conducted to evaluate the safety and recommended dose of intrathecal (IT) nivolumab, given alongside intravenous (IV) nivolumab, for treating patients with melanoma and leptomeningeal disease (LMD).
- The study, which involved 25 metastatic melanoma patients, found no dose-limiting toxicities, establishing the safe IT nivolumab dose at 50 mg administered with 240 mg of IV nivolumab every two weeks.
- The median overall survival (OS) was 4.9 months, with 44% of patients alive at 26 weeks and 26% at 52 weeks, indicating potential effectiveness while
Based on the discrete definition of biological regulatory networks developed by René Thomas, we provide a computer science formal approach to treat temporal properties of biological regulatory networks, expressed in computational tree logic. It is then possible to build all the models satisfying a set of given temporal properties. Our approach is illustrated with the mucus production in Pseudomonas aeruginosa.
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