Publications by authors named "M-C Loureiro"
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.
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- * Diagnosis is based on recognizing specific characteristics of the lesions and the chronic nature of the disease, without the need for definitive biological tests or biopsies.
- * Treatment options depend on the disease's severity and can involve antibiotics, hormonal therapies, and surgery, with imaging techniques like high-frequency ultrasound being essential for accurate assessment and monitoring of the condition.
Article Synopsis
- The study aimed to identify fluid biomarkers in cerebrospinal fluid (CSF) for progressive supranuclear palsy (PSP) to aid in developing new therapies, utilizing advanced proteomic analysis methods.
- Researchers analyzed a total of 136 participants across various groups, comparing individuals with PSP (Richardson syndrome) against healthy controls, using sophisticated platforms to assess the presence of specific proteins (SOMAmers) in CSF.
- Findings revealed that many SOMAmers were differentially expressed in PSP patients, indicating potential biomarkers, with three significant biological pathways linked to disease progression identified, including synaptic functions and cytokine interactions.
The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations () compared to 39 noncarrier controls. Network analysis identified 31 protein co-expression modules.
View Article and Find Full Text PDFThe identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations contribute to oncogenic transformation and in targeting the pathway. A phenotypic screen identified compounds that interfere with trafficking of Notch and induce apoptosis via an endoplasmic reticulum (ER) stress mechanism. Target identification approaches revealed a role for SLC39A7 (ZIP7), a zinc transport family member, in governing Notch trafficking and signaling.
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