Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife: The PESA Observational Study.

Background: APOE is a known genetic contributor to cardiovascular disease, but the differential role alleles play in subclinical atherosclerosis remains unclear.

Methods: The PESA (Progression of Early Subclinical Atherosclerosis) is an observational cohort study that recruited 4184 middle-aged asymptomatic individuals to be screened for cardiovascular risk and multiterritorial subclinical atherosclerosis. Participants were -genotyped, and omics data were additionally evaluated.