Publications by authors named "M-C Bertholet"
Article Synopsis
- RNA vaccines have shown effectiveness against SARS-CoV-2, and a new two-dose self-amplifying mRNA vaccine has been tested for immunity, safety, and distribution in preclinical models.
- In mice, the vaccine generated a strong immune response, neutralizing both the original Wuhan strain and several variants (Alpha, Beta, Delta).
- It demonstrated a good safety profile in rats and hamsters, effectively reducing viral loads and protecting against COVID-19 without causing harmful side effects, leading to its advancement to phase 1 clinical trials.
