Publications by authors named "M-A Bartoli"
Article Synopsis
- Some patients with metastatic melanoma (a type of skin cancer) don't get better from usual treatments. Scientists are looking at personalized medicine, which means tailoring treatment to the patient’s specific cancer.
- In a study, 26 patients who found specific genetic changes in their cancer received personalized treatments, with some seeing good results.
- The study showed that using advanced testing followed by targeted therapy might help patients whose melanoma didn't respond to regular treatments.
Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor of cardiac hypertrophy and heart failure but the relevance of Orai1 is still unclear.
Methods: To test the role of these Orai1 channels in the cardiac pathophysiology, a transgenic mouse was generated with cardiomyocyte-specific expression of an ion pore-disruptive Orai1 mutant (C-dnO1).
Background Gastrointestinal bleeding from angiodysplasia is a major problem in continuous-flow left ventricular assist device (LVAD) patients. LVAD shear stress causes pathologic degradation of VWF (von Willebrand factor). A mechanistic relationship between VWF degradation and angiodysplasia has not been explored.
View Article and Find Full Text PDFRationale: The objective of this autopsy study was to determine whether gastrointestinal angiodysplasia develops during continuous-flow left ventricular assist device (LVAD) support.
Objective: LVAD support causes pathologic degradation of von Willebrand factor (vWF) and bleeding from gastrointestinal angiodysplasia at an alarming rate. It has been speculated that LVAD support itself may cause angiodysplasia.