Publications by authors named "M van den Heuvel"
Background: Acute cellular rejection (ACR) remains a common complication causing significant morbidity post-liver transplantation. Non-human leukocyte antigen (non-HLA) mismatches were associated with an increased risk of ACR in kidney transplantation. Therefore, we hypothesized that donor-recipient non-HLA genetic mismatch is associated with increased ACR incidence post-liver transplantation.
View Article and Find Full Text PDFBackground And Objective: Proximal spinal muscular atrophy (SMA) is caused by deficiency of the ubiquitously expressed survival motor neuron protein. Although primarily a hereditary lower motor neuron disease, it is probably also characterized by abnormalities in other organs. Brain abnormalities and cognitive impairment have been reported in severe SMA.
View Article and Find Full Text PDFHepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we perform comprehensive analysis of hepatoblastomas and tumor-derived organoids using single-cell RNA-seq/ATAC-seq, spatial transcriptomics, and high-throughput drug profiling. We identify two distinct tumor epithelial signatures: hepatic 'fetal' and WNT-high 'embryonal', displaying divergent WNT signaling patterns.
View Article and Find Full Text PDFArticle Synopsis
- Shortwave-infrared (SWIR) imaging is suggested to improve contrast in fluorescence-guided surgery compared to near-infrared (NIR) imaging, but it has only been tested in animal studies so far.
- The study aims to evaluate the benefits of SWIR imaging in clinical samples treated with the NIR dye cetuximab-IRDye800CW, focusing on tumor-targeted applications in penile and head and neck cancers.
- Results indicate that while SWIR performs similarly to NIR in penile cancer samples, NIR outperforms SWIR in most criteria for head and neck cancer due to high background autofluorescence, suggesting that SWIR may enhance contrast in some situations but not universally across all clinical
Introduction: Adagrasib is an upcoming anticancer treatment for KRAS G12C-mutated non-small-cell lung carcinoma, colorectal cancer and potentially other solid tumors harboring this mutation. It is generally well-tolerated and reports of neurological adverse events so far have been limited.
Case Presentation: We present to our best knowledge the first case of a 70-year-old woman who was admitted with polyradiculitis as a treatment-related complication of adagrasib.