Publications by authors named "M van den Hauwe"
Classifying gait patterns into homogeneous groups could enhance communication among healthcare providers, clinical decision making and clinical trial designs in boys with Duchenne muscular dystrophy (DMD). Sutherland's classification has been developed 40 years ago. Ever since, the state-of-the-art medical care has improved and boys with DMD are now longer ambulatory.
View Article and Find Full Text PDFRespiratory complications are common in spinal muscular atrophy (SMA) and significantly contribute to morbidity and mortality in these patients. Generalized respiratory and bulbar muscle weakness translates into diverse and complex clinical consequences necessitating strict follow-up and specialized care. The natural history of SMA has evolved drastically in recent years as a result of the introduction of novel, disease-modifying therapies.
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- - The study investigates how the enzyme ADAM17 regulates the shedding of glycoprotein Ibα (GPIbα) in platelets, focusing on the timing and location of this process, which is essential for understanding platelet activation and function.
- - Researchers used advanced techniques such as electron microscopy and quantitative western blotting to find that ADAM17 is predominantly located inside platelets and that specific strong stimuli, like thrombin and collagen, trigger GPIbα shedding, which occurs much slower than typical blood clotting responses.
- - The findings indicate that there are two different GPIbα populations in platelets: one on the surface involved in clotting and another that is protected within the platelets until stimulation,
Instrumented strength assessment in typically developing children and children with a neural or neuromuscular disorder: A reliability, validity and responsiveness study.
Front Physiol
October 2022
The aim of this study was to determine the clinimetric properties, i.e., reliability, validity and responsiveness of an instrumented strength assessment in typically developing (TD) children and children with cerebral palsy (CP) and Duchenne muscular dystrophy (DMD).
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