Publications by authors named "M van Zyl"

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Given its often-paroxysmal nature, screening at a single time point, using a 12-lead electrocardiogram (ECG) or a Holter monitor, has limited benefit. The AliveCor KardiaMobile device is a validated ECG recorder that can be used for patient-directed arrhythmia diagnosis and symptom-rhythm correlation.

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We introduce the general mathematical framework of variational Hirshfeld partitioning, wherein the best possible approximation to a molecule's electron density is obtained by minimizing the -divergence between the molecular density and a non-negative linear combination of (normalized) basis functions. This framework subsumes several existing methods that variationally optimize their pro-atoms, like (Gaussian) iterative stockholder analysis (ISA and GISA) and minimal basis iterative stockholder partitioning (MBIS), and provides a solid foundation for developing mathematically rigorous partitioning schemes. In this paper, we delve into the mathematical underpinnings of Hirshfeld-inspired partitioning schemes and show that among all the valid -divergence measures only the extended Kullback-Leibler is a suitable choice.

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Article Synopsis
  • Abnormalities found in invasive electroanatomic mapping (EAM) are linked to myocardial issues in Arrhythmogenic Cardiomyopathy (ACM), but EAM parameters are not currently included in the diagnostic guidelines for ACM.
  • A 41-year-old woman experienced frequent PVCs, and while her heart's structure appeared normal on imaging, EAM indicated problems in certain areas of the heart consistent with RV cardiomyopathy.
  • The case highlights that advanced RV electropathy can appear before observable structural heart changes, suggesting that future ACM guidelines might need to incorporate EAM findings for better diagnosis, especially in patients with multiple PVCs.
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The primary healthcare (PHC) rotation places medical students in rural district hospitals for 4 weeks during their 4th or 5th year. This rotation is a collaboration among three academic units at Stellenbosch University's Faculty of Medicine and Health Sciences. Learning activities during this rotation include participation in a longitudinal community-oriented primary care project, conducting rehabilitation-oriented home visits to persons with disabilities, and assessing and treating patients presenting with undifferentiated problems on an in- and outpatient basis.

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