Publications by authors named "M van Wely"
Ectopic pregnancy, defined as the implantation of a developing pregnancy outside of the endometrial cavity of the uterus, is the leading cause of early-pregnancy maternal mortality. The majority of ectopic pregnancies implant in a fallopian tube. Acute complications may include rupture of the fallopian tube or rupture of ectopic pregnancy, haemorrhage and hypovolaemic shock, or occur secondary to treatments such as emergency surgery or blood transfusions, and ultimately increase the risk of maternal death.
View Article and Find Full Text PDFTubal flushing with oil-based contrast during hysterosalpingography versus tubal flushing by hysterosalpingo-foam sonography in infertile women undergoing fertility work-up: study protocol of a randomised controlled trial (FOil study).
BMJ Open
November 2024
Introduction: Hysterosalpingography (HSG) and hysterosalpingo-foam sonography (HyFoSy) are commonly used tubal patency tests during the fertility work-up. Besides its diagnostic purpose, HSG with oil-based contrast can also be applied for its fertility-enhancing effect, by tubal flushing. HyFoSy is considered as less painful compared with HSG, it lacks exposure to iodinated contrast medium and ionising radiation.
View Article and Find Full Text PDFObjective: To investigate pregnant women's preferences for risks of vaginal and caesarean birth, including possible impacts on future fertility.
Methods: In this discrete choice experiment, low-risk nulliparous pregnant women recruited after 28 weeks of gestation evaluated eight choice sets, each between two different hypothetical births scenarios which intermixed the risks of planned caesarean or vaginal birth. Scenarios consisted of six attributes: pain, maternal health, neonatal health, risk of unplanned intervention, impact on fertility and risk of complications in the next pregnancy.
Functional and morphological improvement of significant non-culprit coronary artery stenosis by LDL-C reduction with a PCSK9 antibody: Rationale and design of the randomized FITTER trial.
Heliyon
October 2024
Article Synopsis
- * Patients in the trial receive either evolocumab or a placebo for 12 weeks, alongside high-intensity statin therapy, and are monitored for changes in plaque size and composition using advanced imaging techniques.
- * This study is notable for being the first to assess how significant reductions in low-density lipoprotein cholesterol (LDL-C) could impact the health of non-critical coronary lesions shortly after treatment.
Article Synopsis
- - The study evaluated the safety and efficacy of using an upper-extremity approach for secondary access during transfemoral transcatheter aortic valve implantation (TAVI) compared to the traditional lower-extremity method, as it may reduce significant bleeding risks.
- - Conducted between November 2022 and November 2023 in the Netherlands, the TAVI XS trial involved 238 patients with severe aortic stenosis, who were randomly assigned to either the upper or lower access groups.
- - Results showed that the upper-extremity approach had a lower incidence of clinically relevant bleeding (4.2% vs. 13.4% for the lower extremity), suggesting it could be a safer option for patients undergoing