Publications by authors named "M van Royen"
The androgen receptor (AR), a member of the nuclear steroid hormone receptor family of transcription factors, plays a crucial role not only in the development of the male phenotype but also in the development and growth of prostate cancer. While AR structure and AR interactions with coregulators and chromatin have been studied in detail, improving our understanding of AR function in gene transcription regulation, the spatio-temporal organization and the role of microscopically discernible AR foci in the nucleus are still underexplored. This review delves into the molecular mechanisms underlying AR foci formation, focusing on liquid-liquid phase separation and its role in spatially organizing ARs and their binding partners within the nucleus at transcription sites, as well as the influence of 3D-genome organization on AR-mediated gene transcription.
View Article and Find Full Text PDFThe Gleason score is the gold standard for grading of prostate cancer (PCa) and is assessed by assigning specific grades to different microscopical growth patterns. Aside from the Gleason grades, individual growth patterns such as cribriform architecture were recently shown to have independent prognostic value for disease outcome. PCa grading is performed on static tissue samples collected at one point in time, whereas in vivo epithelial tumour structures are dynamically invading, branching and expanding into the surrounding stroma.
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- The mpox outbreak in 2022-2023 led to widespread vaccination using a vaccine called MVA-BN (also known as JYNNEOS or Imvanex).
- Research shows that orthopoxvirus-specific antibodies, which protect against the virus, decreased to undetectable levels one year after a two-dose MVA-BN vaccination in at-risk individuals.
- Ongoing monitoring is crucial to assess how the decline in antibody levels affects immunity in the population.
Article Synopsis
- Intra-tumor heterogeneity complicates cancer treatment by contributing to therapy resistance and disease recurrence, but its underlying mechanisms are not well understood.
- Researchers studied the SW480 colon cancer cell line to explore this diversity and found three distinct subpopulations: resident cancer stem cells (rCSCs), migratory CSCs (mCSCs), and high-relapse cells (HRCs).
- These subpopulations exhibit different levels of Wnt signaling and gene expression, and spatial transcriptomic data from patient tumors supports their existence and varying distribution in the tumor microenvironment.
BackgroundFollowing the 2022-2023 mpox outbreak, crucial knowledge gaps exist regarding orthopoxvirus-specific immunity in risk groups and its impact on future outbreaks.AimWe combined cross-sectional seroprevalence studies in two cities in the Netherlands with mathematical modelling to evaluate scenarios of future mpox outbreaks among men who have sex with men (MSM).MethodsSerum samples were obtained from 1,065 MSM attending Centres for Sexual Health (CSH) in Rotterdam or Amsterdam following the peak of the Dutch mpox outbreak and the introduction of vaccination.
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