Publications by authors named "M van Lohuizen"
Background: More than half of mesothelioma tumours show alterations in the tumour suppressor gene BAP1. BAP1-deficient mesothelioma is shown to be sensitive to EZH2 inhibition in preclinical settings but only showed modest efficacy in clinical trial. Adding a second inhibitor could potentially elevate EZH2i treatment efficacy while preventing acquired resistance at the same time.
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- Bladder cancers with mutations in chromatin regulatory genes show that targeting EZH2 is crucial for treatment, as these mutations oppose Polycomb-mediated repression.
- *The study aims to enhance therapeutic response by simultaneously targeting EZH2 and retinoic acid signaling, leveraging their anti-cancer effects.
- *Results indicate that this dual targeting leads to reduced cell viability, increased cell death, and cell cycle arrest, illustrating a potential strategy for developing new treatments using retinoids along with EZH2 inhibitors.
Unlabelled: Malignant mesothelioma is a highly aggressive tumor with a survival of only 4-18 months after diagnosis. Treatment options for this disease are limited. Immune checkpoint blockade using ipilimumab and nivolumab has recently been approved as a frontline therapy, but this led to only a small improvement in overall patient survival.
View Article and Find Full Text PDFMore than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive deubiquitinating (PR-DUB) complex, BAP1 loss results in an altered epigenome, which may create new vulnerabilities that remain largely unknown. Here, we performed a CRISPR-Cas9 kinome screen in mesothelioma cells that identified two kinases in the mevalonate/cholesterol biosynthesis pathway.
View Article and Find Full Text PDFObjective: This cross-sectional questionnaire study investigates if there a difference in the extent to which health care providers in prenatal Shared Medical Appointments (CenteringPregnancy©) and in prenatal individual appointments support self-management in patient education. It also investigates if there is a difference in the extent to which health care providers in CenteringPregnancy@ and in individual appointments pay attention to the factors of the Integrated Model for Behavioral Change (I-Change) in supporting self-management.
Methods: Dutch health care providers in prenatal care were invited to fill out a questionnaire.