Publications by authors named "M van Lettow"
Article Synopsis
- An analysis of mpox cases in Burundi from July to September 2024 revealed 154 PCR-positive samples out of 607 suspected cases, primarily affecting children under 15.
- Among the positive cases, a notable proportion were female children, highlighting a gender disparity in infections.
- The majority of cases were concentrated in Bujumbura Mairie, underlining the need for age- and sex-specific public health interventions and community engagement for effective outbreak containment.
Direct RNA nanopore sequencing reveals changes in gene expression, polyadenylation, splicing, m6A methylation, and pseudouridylation in response to influenza virus exposure in primary human bronchial epithelial cells. This study focuses on the epitranscriptomic profile of genes in the host immune response. In addition to polyadenylated noncoding RNA, we purified and sequenced nonpolyadenylated noncoding RNA and observed changes in expression, N6-methyl-adenosine (m6A), and pseudouridylation (Ψ) in these novel RNA.
View Article and Find Full Text PDFObjectives: The objective of this study is to assess the outcomes of children, adolescents and young adults with HIV reported as lost to follow-up, correct mortality estimates for children, adolescents and young adults with HIV for unascertained outcomes in those loss to follow-up (LTFU) based on tracing and linkage data separately using data from the International epidemiology Databases to Evaluate AIDS in Southern Africa.
Methods: We included data from two different populations of children, adolescents and young adults with HIV; (1) clinical data from children, adolescents and young adults with HIV aged ≤24 years from Lesotho, Malawi, Mozambique, Zambia and Zimbabwe; (2) clinical data from children, adolescents and young adults with HIV aged ≤14 years from the Western Cape (WC) in South Africa. Outcomes of patients lost to follow-up were available from (1) a tracing study and (2) linkage to a health information exchange.
Article Synopsis
- Protonated fucose-containing oligosaccharides often rearrange during mass spectrometry, creating complex fragments that complicate analysis.
- This study utilizes density functional theory to analyze IR spectra of specific trisaccharides, concluding that they do not undergo rearrangement in the gas phase.
- Key factors for rearrangement include the presence of a mobile proton and the stability differences between the parent ions and their rearranged forms.
Objective: To assess the uptake of services provided by community health workers who were trained as community health entrepreneurs (CHEs) for febrile illness and diarrhoea.
Design: A cross-sectional survey among households combined with mapping of all providers of basic medicine and primary health services in the study area.
Participants: 1265 randomly selected households in 15 rural villages with active CHEs.