Double antibody specificity of lymphoid cells isolated from normal human intestinal mucosa.

Lymphoid cells were isolated from normal human mucosal specimens. A certain fraction of these cells exhibited double antibody specificities at the levels of both light kappa and lambda chains and heavy mu and gamma chains. The variable frequency with which these cells were detected appears to be a characteristic of this population.

Human lymphoid cells of the intestinal mucosa showing specificity for both immunoglobulin light and heavy chains.

The presence of single human lymphoid cells expressing on the one hand both kappa and lambda light chain and on the other hand either both mu and alpha or both mu and gamma heavy chains, was observed in the intestinal mucosa. The variability of the frequency of such cells, both from one subject to another, or in the same sample, is a characteristic of this population.

Reactions induced in vertebrates by invertebrate cell suspensions. II/Non adherent axial organ cells as effector cells.

In contrast to starfish axial organ cells, coelomocytes of Asterias rubens do not induce a significant reaction of angiogenesis after subcutaneous injection into irradiated mice. Axial organ cells are separated into adhering and nonadhering cells by attachment ot plastic surface. Nonadhering cells consisting mainly of small lymphocyte-like cells appear to be effector cells in the reaction.

Reactions induced in vertebrates by invertebrate cell suspensions. I/Specific effects of sea star axial organ cells injection.

Starfish axial organ cell suspensions injected subcutaneously into irradiated mice induce a characteristic angiogenesis reaction. The size of the reaction appears to be dependent upon the number of injected starfish cells. Axial organ cells also provoke a splenomegaly positive test in 16 day old chick embryos.