In vivo measurements of change in tissue oxygen level during irradiation reveal novel dose rate dependence.

Background And Purpose: This study aimed to investigate the radiochemical oxygen depletion (ROD) in vivo by directly measuring oxygen levels in various mouse tissues during ultra-high dose rate (UHDR) irradiation at clinically relevant doses and dose rates.

Materials And Methods: Mice bearing subcutaneous human glioblastoma (U-87 MG) tumors were used for tumor and normal tissue (skin, muscle, brain) measurements. An oxygen-sensitive phosphorescent probe (Oxyphor PtG4) was injected into the tissues, and oxygen levels were monitored using a fiberoptic phosphorometer during UHDR irradiation with a 6 MeV electron linear accelerator (LINAC).

Intelligent system based on multiple networks for accurate ovarian tumor semantic segmentation.

Ovarian tumors, especially malignant ones, represent a global concern, with increased prevalence in recent years. More accurate medical support systems are urgently needed to support medical staff in obtaining an efficient ovarian tumors diagnosis since detection in early stages could lead to immediately applying appropriate treatment, and implicitly improving the survival rate. The current paper aims to demonstrate that more accurate systems could be designed by combining different convolutional neural networks using different custom combination approaches and by selecting the appropriate networks to be involved in the ensemble model to achieve the best performance metrics.

Electrospun poly(ε-caprolactone)/poly(glycerol sebacate) aligned fibers fabricated with benign solvents for tendon tissue engineering.

The electrospinning technique is a commonly employed approach to fabricate fibers intended for various tissue engineering applications. The aim of this study is to develop a novel strategy for tendon repair through the use of aligned poly(ε-caprolactone) (PCL) and poly(glycerol sebacate) (PGS) fibers fabricated in benign solvents, and further explore the potential application of PGS in tendon tissue engineering (TTE). The fibers were characterized for their morphological and physicochemical properties; amniotic epithelial stem cells (AECs) were used to assess the fibers teno-inductive and immunomodulatory potential due to their ability to teno-differentiate undergoing first a stepwise epithelial to mesenchymal transition, and due to their documented therapeutic role in tendon regeneration.