Publications by authors named "M del Mar Serna"
Background: Serious Illness Conversations (SICs) are not consistently integrated into existing inpatient workflows.
Objective: We assessed the implementation of multiple interventions aimed at encouraging SICs with hospitalized patients.
Methods: We used the Consolidated Framework for Implementation Research to identify determinants for conducting SICs by interviewing providers and the Expert Recommendations for Implementing Change to develop a list of interventions.
SETD8 is a methyltransferase that is overexpressed in several cancers, which monomethylates H4K20 as well as other non-histone targets such as PCNA or p53. We here report novel SETD8 inhibitors, which were discovered while trying to identify chemicals that prevent 53BP1 foci formation, an event mediated by H4K20 methylation. Consistent with previous reports, SETD8 inhibitors induce p53 expression, although they are equally toxic for p53 proficient or deficient cells.
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- Cells regulate microtubule formation through the γ-tubulin ring complex (γTuRC), which has an open ring structure that doesn’t align with microtubule symmetry.
- Researchers used cryoelectron microscopy to discover that activation of γTuRC involves the binding of CM1 dimers to five specific sites on the complex, dependent on other regulatory proteins.
- The binding of CM1 enhances interactions between γTuRC components, allowing for microtubule-like shapes and the release of inhibitory actin, leading to increased nucleation activity despite the lack of perfect symmetry.
Article Synopsis
- The study investigated how to identify hospitalized patients who might benefit from serious illness conversations (SICs) by combining Epic's Risk of Readmission Score (RRS) with a simple question about expected mortality ("Would you be surprised if the patient died in the next 12 months?").
- Researchers analyzed patient encounters from January 2019 to October 2021, finding that 77.2% of patients with a high RRS were considered unlikely to survive the next year, and these patients had higher rates of documented SICs.
- Despite a significant portion of these patients needing SICs, the overall rates of having these conversations were very low, suggesting that using both EHR data and
Background: This study aims to examine risk of adverse pregnancy outcomes and mothers' characteristics in patients with chronic hypertension, gestational hypertension and preeclampsia.
Methods: The study included all births born from women aged 15-45 years, in Lleida, Spain from 2012 to 2018. Pregnancy outcomes were retrieved by regional administrative databases.