Publications by authors named "M del Mar Espino"

Background: Diaphorina citri is an insect vector of "Candidatus Liberibacter asiaticus" (CLas), the gram-negative bacterial pathogen associated with citrus greening disease. Control measures rely on pesticides with negative impacts on the environment, natural ecosystems, and human and animal health. In contrast, gene-targeting methods have the potential to specifically target the vector species and/or reduce pathogen transmission.

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Objective: To ascertain the changes of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) values in relapsing-remitting multiple sclerosis (RRMS) patients treated with ocrelizumab and their association with treatment response.

Methods: Multicenter prospective study including 115 RRMS patients initiating ocrelizumab treatment between February 2020 and March 2022 followed during a year. Serum samples were collected at baseline and every 3 months to measure sNfL and sGFAP levels using single-molecule array (SIMOA) technology.

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Article Synopsis
  • *This study examined brain samples from 70 rabid dogs, finding high presence of Negri bodies in the hippocampus (87.14%) and cerebrum (70%), with distinct characteristics in those regions compared to the thalamus and brainstem.
  • *The research highlighted that detecting Negri bodies in the hippocampus and cerebral cortex can aid in rabies diagnosis, while immunohistochemistry showed high sensitivity for identifying rabies virus antigens in all brain regions studied.
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  • * A study of 52 confirmed SFT cases used immunohistochemical analysis of various markers to investigate their correlation with patient outcomes and existing risk stratification systems.
  • * Results indicated that immune cell presence didn't significantly impact prognosis, but one case with high immune infiltrate showed progression; certain immune markers revealed associations with tumor characteristics and behaviors, suggesting complex interactions in the tumor microenvironment.
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