Publications by authors named "M del Mar Arroyo-Jimenez"
Neurodegeneration associated with ageing is closely linked to oxidative stress (OS) and disrupted calcium homeostasis. Some areas of the brain, like the hippocampus - particularly the CA1 region - have shown a high susceptibility to age-related changes, displaying early signs of pathology and neuronal loss. Antioxidants such as α-tocopherol (αT) have been effective in mitigating the impact of OS during ageing.
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- Current understanding of tau neurofibrillary tangles (NFTs) in Alzheimer's Disease is hindered by other non-AD pathologies and limitations of conventional two-dimensional histological methods.
- The study combines ex vivo MRI and serial histological imaging from 25 human medial temporal lobe specimens to create a high-resolution 3-D atlas that maps the distribution of NFT burden.
- Findings reveal a gradient in NFT distribution from anterior to posterior in the medial temporal lobe, with highest concentrations in specific regions, suggesting certain areas may serve as early biomarkers for neurodegeneration in Alzheimer's Disease.
Article Synopsis
- * The study compares cytoarchitectonic definitions of MTL cortex subregions, specifically focusing on the entorhinal, parahippocampal cortices, and Brodmann areas (BA) 35 and 36, as defined by four different neuroanatomists.
- * Findings indicate that there is a high agreement on the definitions of the entorhinal cortex and BA35, but less consensus on BA36 and the parahippocampal cortex, especially in transitional areas.
We present a method for human brain fixation based on simultaneous perfusion of 4% paraformaldehyde through carotids after a flush with saline. The left carotid cannula is used to perfuse the body with 10% formalin, to allow further use of the body for anatomical research or teaching. The aim of our method is to develop a vascular fixation protocol for the human brain, by adapting protocols that are commonly used in experimental animal studies.
View Article and Find Full Text PDFLittle information is available on the magnetic resonance imaging (MRI) determination of the hippocampal formation (HF) during the perinatal period. However, this exploration is increasingly used, which requires defining visible HF landmarks on MRI images, validated through histological analysis. This study aims to provide a protocol to identify HF landmarks on MRI images, followed by histological validation through serial sections of the temporal lobe of the samples examined, to assess the longitudinal extent of the hippocampus during the perinatal period.
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