Drug Development.

Background: Reactive astrocytes and neuron death by excitotoxicity are observed in Alzheimer's disease (AD). DHA-H (2-hydroxy-docosahexaenoic acid; 2-OH-C22:6 n-3) is a molecule under development that has demonstrated therapeutic efficacy in both cellular and 5xFAD mouse model of AD. DHA-H is metabolized through α-oxidation to yield HPA (Heneicosapentaenoic acid; C21:5 n-3).

Catalytic Oxidation of Acetone over MnO-SiO Catalysts: An Effective Approach to Valorize Rice Husk Waste.

Rice husk, a byproduct of rice production, poses significant environmental challenges due to disposal issues, while the emission of volatile organic compounds into the atmosphere further exacerbates these concerns. This study addresses both problems by exploring the potential of texturally enhanced SiO, derived from Uruguayan rice husk, as a catalytic support for manganese oxides in the combustion of volatile organic compounds. SiO was synthesized from rice husk ash using a sustainable, acid-free pretreatment method, yielding a notably high silica purity of 96.

Venomics AI: a computational exploration of global venoms for antibiotic discovery.

The relentless emergence of antibiotic-resistant pathogens, particularly Gram-negative bacteria, highlights the urgent need for novel therapeutic interventions. Drug-resistant infections account for approximately 5 million deaths annually, yet the antibiotic development pipeline has largely stagnated. Venoms, representing a remarkably diverse reservoir of bioactive molecules, remain an underexploited source of potential antimicrobials.

Trends of Self-Reported Health Consequences of Violence from 2000 to 2018 and Associated Factors in Mexican Adolescents and Adult Women at the National Level.

Violence has negative effects on women's physical, mental, sexual, reproductive, and behavioral health. Globally, 50% to 80% of women who have experienced violence suffer some health consequences. We aimed to evaluate the prevalence and trends of self-reported health consequences of violence among Mexican adolescents and women from 2000 to 2018.