Publications by authors named "M de Steenwinkel"
Background: Patient satisfaction is an important indicator of emergency care quality and has been associated with information dispensation at the emergency department (ED). Optimal information dispensation could improve patient experience and expectations. Knowing what kind of information patients want to receive and the preferred way of information dispensation are essential to optimize information delivery at the ED.
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- The study examines the surgical treatment of rib fracture nonunion, highlighting a lack of existing literature on this issue.
- Nineteen patients with symptomatic nonunions participated, showing a mean follow-up of 36 months; most reported satisfaction with results and a decrease in complaints, albeit persistent pain was still common.
- The research concludes that surgical fixation for rib nonunion is a safe option with low complication rates and could be beneficial for certain patients in the future.
Dietary omega-3 polyunsaturated fatty acids (omega-3 PUFAs) protect against photocarcinogenesis in animals, but prospective human studies are scarce. The mechanism(s) underlying the photoprotection are uncertain, although omega-3 PUFAs may influence oxidative stress. We examined the effect of supplementation on a range of indicators of ultraviolet radiation (UVR)-induced DNA damage in humans, and assessed effect on basal and post-UVR oxidative status.
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- The study investigated human exposure to methyl bromide (MeBr), a substance used for soil sterilization in greenhouses, and its potential to cause DNA damage.
- Blood samples were collected from exposed individuals and non-exposed controls, with some showing positive results for N7-methylguanine, a DNA adduct linked to MeBr exposure, but no positive results for O6-methylguanine.
- Ultimately, the study concluded that there was no significant evidence of DNA damage in blood leukocyte DNA due to MeBr exposure, within the study's limitations.
The goal of this investigation was to correlate the melanin content in human pigmentary cells with the generation of UVB-induced photoproducts and to examine the relationship between the melanin content and the removal of the photoproducts. Cultured melanocytes from light-skinned individuals synthesized less melanin and produced more cyclobutane pyrimidine dimers and 6-4 photoproducts upon UVB exposure than did melanocytes from black skin. Tyrosine-stimulated melanogenesis provided protection against DNA damage in both cell types.
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