Publications by authors named "M de Mendoza"
Small fetuses, with estimated fetal weight (EFW) below the tenth percentile, are classified as fetal growth restriction (FGR) or small for gestational age (SGA) based on prenatal ultrasound. FGR fetuses have a greater risk of stillbirth and perinatal complications and may benefit from serial ultrasound scans to guide early delivery. Abnormal serum angiogenic factors, such as the soluble fms-like tyrosine kinase-1 (sFlt-1):placental growth factor (PlGF) ratio, have shown potential to more accurately distinguish FGR from SGA, with fewer false positives.
View Article and Find Full Text PDFRepair of the pulmonary vascular bed and the origin of new vasculature remain underexplored despite the critical necessity to meet oxygen demands after injury. Given their critical role in angiogenesis in other settings, we investigated the role of venous endothelial cells in endothelial regeneration after adult lung injury. Here we identified Slc6a2 as a marker of pulmonary venous endothelial cells and generated a venous-specific, inducible Cre mouse line.
View Article and Find Full Text PDFObjectives: To assess the performance of mean uterine artery pulsatility index (UtA-PI) at 18-22 and 24-28 weeks of gestation in the prediction of pre-eclampsia (PE) and small-for-gestational age (SGA), and its role in reassessing the risk of PE and SGA in pregnancies screened for PE in the first trimester.
Methods: This was a retrospective observational cohort study of 4464 women with singleton pregnancy screened routinely for PE in the first trimester, using the Gaussian algorithm, from March 2019 to May 2021, and who underwent UtA-PI assessment at 18-22 gestational weeks. Women were categorized as low risk or high risk based on the risk index obtained after first-trimester screening for PE.
Article Synopsis
- A phase 1 study investigated the safety and feasibility of transplanting spinal cord-derived neural stem cells (NSI-566) for chronic spinal cord injuries, focusing on four participants with specific injuries.
- All participants tolerated the stem cell procedure well without major complications.
- After five years, two participants showed significant neurological improvements, with measurable gains in motor and sensory functions.
Article Synopsis
- Overhead evaporative cooling (EC) using untreated surface water helps reduce sunburn on apples in Washington State, but it poses a risk of foodborne pathogen contamination, specifically E. coli.
- The study investigated the survival of E. coli on two apple varieties (Gala and Golden Delicious) over three growing seasons, examining factors like EC treatment, canopy location, and fruit maturity.
- E. coli levels decreased significantly during the study, with detection still possible after 154 hours; apple variety and maturity affected die-off rates, while EC treatment and canopy location did not significantly influence daily die-off rates.