Hyperactive delta isoform of PI3Kinase enables long distance regeneration of adult rat corticospinal tract.

Neurons in the central nervous system (CNS) lose regenerative potential with maturity, leading to minimal corticospinal tract (CST) axon regrowth after spinal cord injury (SCI). In young rodents, knockdown of PTEN, which antagonises PI3K signalling by hydrolysing PIP3, promotes axon regeneration following SCI. However, this effect diminishes in adults, potentially due to lower PI3K activation leading to reduced PIP3.

Mitigation of Salt Stress in L. var. Gentile Rossa Using Microalgae as Priming Agents.

Using renewable biomass in agriculture, particularly microalgae as a biostimulant, offers economic and environmental sustainability benefits by reducing costs, improving nutrient cycling, and enhancing water use efficiency. Microalgae contain bioactive compounds that boost crop tolerance to environmental stresses, including salinity. Saline soils, characterized by elevated sodium chloride (NaCl) levels, negatively impact many crops, resulting in low productivity and high remediation costs.

Chemistry of Street Art: Neural Network for the Spectral Analysis of Berlin Wall Colors.

This research starts with the analysis of some fragments of the Berlin Wall street art for the characterization of the painting materials. The spectroscopic results provide a general description of the paint executive technique but more importantly open the way to a new advantage of Raman application to the analytic analysis of acrylic colors. The study highlights the correlation between peak intensity and compound percentage and explores the powerful application of deep learning for the quantification of a pigment mixture in the acrylic commercial products from Raman spectra acquired with hand-held equipment (BRAVO by Bruker).

A new species of Pachysvastra Moure & Michener (Hymenoptera: Apidae) discovered in Argentina.

A new species, Pachysvastra luquita, is described and figured from northeastern Argentina, which extends the range of the genus. An identification key for the three known species of Pachysvastra and updated occurrence records are given.

Impact of diabetes on epicardial reperfusion and mortality in a contemporary STEMI population undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry.

Background And Aim: Diabetes has been shown in last decades to be associated with a significantly higher mortality among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary PCI (PPCI). Therefore, the aim of current study was to evaluate the impact of diabetes on times delays, reperfusion and mortality in a contemporary STEMI population undergoing PPCI, including treatment during the COVID pandemic.

Methods And Results: The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry involving PPCI centers from Europe, Latin America, South-East Asia and North-Africa, including patients treated from 1st of March until June 30, 2019 and 2020.