Publications by authors named "M Zwaan"

Background: Obesity shows significant association with depression elevating morbidity burden. Obesity surgery (OS) has been proven as an effective therapy reducing weight as well as depression prevalence rates, though the latter decrease appears to be unstable over time. For a better interpretation of the time trend, data on depression prevalence in OS-patients for the period before the surgery are needed.

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Background: A large number of individuals suffer from post-COVID-19 condition (PCC), characterised by persistent symptoms following a SARS-CoV-2 infection with an impact on daily personal and professional activities. This study aims at examining which (health) care services are used by PCC patients in the German federal state of Lower Saxony, and how these patients manage their condition. The perspectives of patients, informal caregivers and general practitioners (GPs) will be considered.

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Article Synopsis
  • The study investigated the CTBP2 gene and its relation to anorexia nervosa (AN) and body mass index (BMI) through mutation analysis, revealing 24 variants in the RIBEYE exon among various groups including patients with AN, obese children, and healthy individuals.
  • Three rare non-synonymous variants were found in AN patients, while several variants were unique to children with severe obesity, indicating potential genetic links to these conditions.
  • Functional studies showed that RIBEYE mRNA is expressed in the mouse hypothalamus and is influenced by leptin treatment, suggesting that the RIBEYE gene may play a role in body weight regulation.
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Introduction: While ample data demonstrate the effectiveness of inpatient psychosomatic treatment, clinical observation and empirical evidence demonstrate that not all patients benefit equally from established therapeutic methods. Especially patients with a comorbid personality disorder often show reduced therapeutic success compared to other patient groups. Due to the heterogeneous and categorical personality assessment, previous studies indicated no uniform direction of this influence.

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Purpose: Previous research on obesity surgery (OS) showed that patients do not only experience weight loss but also improvements in certain mental health outcomes (e.g., depression) after OS.

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