Publications by authors named "M Zutshi"
Article Synopsis
- The study aims to evaluate surgical techniques for treating rectovaginal fistulas in Crohn's disease patients, highlighting the effectiveness of operations in the context of new biological treatments.
- Over a decade, 20 out of 80 patients who underwent surgery were examined, revealing a healing rate of 70%, with a common procedure being the transanal rectal advancement flap, which had an 85% success rate.
- The findings suggest that rectovaginal fistulas are tough to treat, often requiring multiple surgeries, and indicate the potential benefit of considering perioperative diversion along with various surgical options for motivated patients.
The aim of this study is to investigate if a high dose of the (SDF-1) plasmid improves outcome in a minipig model of chronic anal sphincter injury. Twenty-two female minipigs underwent excision of the posterior hemicircumference of the anal sphincter complex and were allowed to recover for 6 weeks. They were randomly allocated ( = 6) to receive either 5% dextrose (sham) or 2, 4, or 8 mg of SDF-1 plasmid at the defect site.
View Article and Find Full Text PDFStromal cell derived factor 1 plasmid to regenerate the anal sphincters.
J Tissue Eng Regen Med
April 2022
Unlabelled: The aim of this study was to evaluate regeneration of a chronic large anal sphincter defect in a pig model after treatment with a plasmid encoding Stromal Cell Derived Factor-1(SDF-1).
Methods: Under ethics approved protocol 19 age/weight matched Sinclair mini-pigs were subjected to excision of the posterior 50% of anal sphincter muscle and left to recover for 6 weeks. They were randomly allocated to receive either saline treatment (Saline 1 ml, n = 5), 1 injection of SDF-1 plasmid 2 mg/ml (1 SDF-1, n = 9) or 2 injections of SDF-1, 2 mg/ml each at 2 weeks intervals (2 SDF-1, n = 5).
Benign anorectal disorders of structure and function are common in clinical practice. These guidelines summarize the preferred approach to the evaluation and management of defecation disorders, proctalgia syndromes, hemorrhoids, anal fissures, and fecal incontinence in adults and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was assessed using the Grading of Recommendations Assessment, Development and Evaluation process.
View Article and Find Full Text PDFBackground: There are many surgical options for the treatment of rectal prolapse with varying recurrence rates reported. The association between rectal prolapse length and recurrence risk has not been explored previously.
Objective: The purpose of this study was to determine whether length of prolapse predicts a risk of recurrence.