The review presents new ideas about developmental mechanisms of amblyopia, which are currently discussed in literature. Objective evidence has accumulated that amblyopia affects both monocular and binocular functions in visual processing. Given the increasing evidence of fundamental and clinical research, it is most likely that binocular dysfunction is primary, and monocular reduction is visual acuity is secondary to this disease.
View Article and Find Full Text PDFThe neuroplasticity potential is reduced with aging and impairs during neurodegenerative diseases and brain and visual system injuries. This limits the brain's capacity to repair the structure and dynamics of its activity after lesions. Maximization of neuroplasticity is necessary to provide the maximal CNS response to therapeutic intervention and adaptive reorganization of neuronal networks in patients with degenerative pathology and traumatic injury to restore the functional activity of the brain and retina.
View Article and Find Full Text PDFUnlabelled: Various animal models of atrophy of retinal pigment epithelium (RPE) are created in order to study certain aspects of geographical atrophy in humans. To study the effects of new methods of therapy, it is necessary to determine the objective functional markers of structural changes in the retina.
Purpose: To determine the alterations in activity of the retina that characterize its remodeling in induction of RPE atrophy.
Unlabelled: The clinical sugnificance of electroretinogram interpretation depends heavily on the employed mathematical apparatus. Currently, conventional calculation of the amplitude and time parameters of electroretinogram (ERG) components and their relations (indices), as well as analysis of the frequency spectrum of the signal are becoming insufficient for interpretation of the obtained data. New approaches to diagnostics are currently being developed, using, among other things, expert systems, and neural network and simulation models.
View Article and Find Full Text PDF