MRI of two infants with tuberous sclerosis.

Two children (4 1/2 and 9 months of age) suffering from tuberous sclerosis were examined with MRI, using a 2.35-Tesla magnet. Both patients showed the typical brain lesions of tuberous sclerosis, namely, subependymal nodules projecting into the lateral ventricles and parenchymal hamartomas.

MR imaging of intracranial hemorrhage in neonates and infants at 2.35 Tesla.

The variations of the relative signal intensity and the time dependent changing contrast of intracranial hemorrhages on high-field spin-echo magnetic resonance images (MRI) were studied in 28 pediatric patients. For T1-weighted images, a repetition time (TR) of 500 ms and an echo time (TE) of 30 or 23 ms was used. The corresponding times for T2-weighted images were TR 3000 ms and TE 120 ms.

MR imaging of brain maturation in normal and developmentally handicapped children.

White matter myelination was assessed in the frontal, temporal, and occipital lobes and in the internal capsule in 91 neurodevelopmentally handicapped infants on T2-weighted images (spin echo 3,000/120 ms) and compared with myelination scores from 53 normal control subjects. Clinical diagnosis was birth asphyxia (34), seizures with delays of various causes (33), congenital infections (15), and intracerebral hemorrhages (9). Myelination in the total group of patients was generally delayed.

Developmental stages of human brain: an MR study.

The differentiation of the telencephalon (TC) gyri and the myelination of TC and diencephalon were analyzed quantitatively in 50 children, 32-240 weeks' postconceptional age (PCA). For this purpose, a four-stage grading system was developed by correlating magnetic resonance images from age-matched postmortem brains with subsequently prepared myelin-stained macroslices. Gyration and myelination progressed in a occipito-rostral direction.