Temperament and executive functioning correlates of ADHD symptom severity during early versus middle childhood.

Background: This study investigated associations among temperament, executive functioning (EF), and attention-deficit/hyperactivity disorder (ADHD) symptom severity at two developmental stages.

Methods: Participants were 61 4-year-old children and 165 8-11-year-old children (126 ADHD, 39 typically developing [TD]). Caregivers reported on temperament (effortful control [EC], negative affect, and surgency), and ADHD symptoms.

EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development.

Background: Aperiodic resting electroencephalography (EEG) activity is dynamic, reflecting shifting excitatory:inhibitory (E:I) balance with changing environmental conditions. We examined developmental and cognitive correlates of aperiodic and dynamic aperiodic indices in a cross-sequential cohort of early, middle, and late childhood youth with and without attention deficit hyperactivity disorder (ADHD).

Methods: Two-hundred eighty-five children ages 2 - 14 years provided resting EEG during high- and low-visual input conditions.

High-Throughput Microscopy Characterization of Rare Variants.

Familial hypercholesterolemia (FH) is the most common inherited life-threatening disorder of lipid metabolism. Early diagnosis and treatment are the key to reduce the cumulative life-long cardiovascular burden of patients with FH. The high number of variants described as variants of unknown significance is the largest obstacle to achieve a definitive FH diagnosis.

Molecular rotations trigger a glass-to-plastic fcc heterogeneous crystallization in high-pressure water.

We report a molecular dynamics study of the heterogeneous crystallization of high-pressure glassy water using (plastic) ice VII as a substrate. We focus on the thermodynamic conditions P ∈ [6-8] GPa and T ∈ [100-500] K, at which (plastic) ice VII and glassy water are supposed to coexist in several (exo)planets and icy moons. We find that (plastic) ice VII undergoes a martensitic phase transition to a (plastic) fcc crystal.

Functional profiling of LDLR variants: Important evidence for variant classification: Functional profiling of LDLR variants.

Background: Familial Hypercholesterolemia (FH) is a semidominant disorder of the lipid metabolism associated with premature atherosclerosis and coronary heart disease. So far, about 3,000 unique LDLR variants have been described, most of which lack functional evidence proving their effect on LDLR function, despite the important role that functional studies play in variant classification.

Objective: In this work, we aimed to functionally characterize 13 rare missense variants, identified worldwide and in Portugal, in clinical FH patients.