On-Demand Polymer Materials for Sustainability and Space.

Production of polymer material goods on-demand is a recurring science fiction element, but advances in chemistry and engineering have pushed it closer to reality. Experienced at a hobby scale by 3D printing enthusiasts and at an industrial level through rapid prototyping and modular manufacturing, the approach is on its way to further flexibility and high-performance material production. We review the advances in on-demand materials design as well as manufacturing, using examples in space exploration and sustainability, because these are cases where the value proposition for rapid changes in materials is strong.

Gene Analysis of Biostimulators: Poly-L-Lactic Acid Triggers Regeneration While Calcium Hydroxylapatite Induces Inflammation Upon Facial Injection.

Background: Injectable biostimulator treatments stimulate endogenous collagen in aging skin, but whether they act through similar pathways is unknown. This study evaluates two biostimulatory agents' effects on genes, expressed proteins, and respective pathways as potential aging biomarkers and treatment outcomes.

Methods: This 13-week, randomized, single-center, comparative study compared volume change and gene expression stimulated by poly-L-lactic acid (PLLA-SCATM) and calcium hydroxylapatite (CaHA-R) via punch biopsy in the nasolabial fold (NLF).

Video Game Therapy in a Neurosciences Critical Care Unit: A Pilot Study.

Background: Therapeutic activity after stroke is a component of early recovery strategies. Interactive video games have been shown to be safe as an adjunct rehabilitation therapy in the medical intensive care setting, but patients with neurologic disease were often excluded from those protocols.

Objectives: To evaluate the feasibility and safety of individualized interactive video game therapy in critically ill neurologic patients.

Intensity of Intrathecal Total IgG Synthesis in Multiple Sclerosis Correlates with the Degree of Pleocytosis, Diversity of Intrathecal Antiviral Antibody Specificities, and Female Sex.

Background: The presence of intrathecal total IgG production is a hallmark of cerebrospinal fluid (CSF) characteristics in multiple sclerosis (MS). Herein, we systematically analyze how the intensity (instead of mere presence) of intrathecal total IgG production relates to basic CSF parameters in MS.

Methods: We retrospectively assessed clinical routine CSF findings from 390 therapy-naïve relapsing-remitting MS patients diagnosed according to 2017 revised McDonald criteria.