Enhancing the Potential of PHAs in Tissue Engineering Applications: A Review of Chemical Modification Methods.

Polyhydroxyalkanoates (PHAs) are a family of polyesters produced by many microbial species. These naturally occurring polymers are widely used in tissue engineering because of their in vivo degradability and excellent biocompatibility. The best studied among them is poly(3-hydroxybutyrate) (PHB) and its copolymer with 3-hydroxyvaleric acid (PHBV).

Longitudinal study of metacognition's role in self-efficacy and hope development.

Self-regulation is a critical component of adaptive functioning, and individual differences in traits like metacognitive self-awareness (MCS), general self-efficacy (GSE), and hope play significant roles in influencing this ability. Self-awareness of cognitive biases is particularly relevant as it may enhance one's capacity to manage challenges and pursue goals effectively. Prior research suggests that higher levels of MCS are associated with improved self-regulation, greater self-efficacy, and stronger hope for success.

Mortality in people with mental disorders in Poland during the COVID-19 pandemic: a nationwide, register-based cohort study.

Purpose Of Review: People with mental disorders in Poland have increased standardized mortality ratios (SMRs). This is the first study to assess all-cause mortality in people with mental disorders in Poland during the COVID-19 pandemic.

Recent Findings: A nationwide, register-based cohort study utilizing data from the registry of healthcare services (2011-2020) and the all-cause death registry (2021) in Poland was conducted.

Dimma: Semi-Supervised Low-Light Image Enhancement with Adaptive Dimming.

Enhancing low-light images with natural colors poses a challenge due to camera processing variations and limited access to ground-truth lighting conditions. To address this, we propose Dimma, a semi-supervised approach that aligns with any camera using a small set of image pairs captured under extreme lighting conditions. Our method employs a convolutional mixture density network to replicate camera-specific noise present in dark images.

μ-Opioid receptor transcriptional variants in the murine forebrain and spinal cord.

Oprm1, the gene encoding the μ-opioid receptor, has multiple reported transcripts, with a variable 3' region and many alternative sequences encoding the C-terminus of the protein. The functional implications of this variability remain mostly unexplored, though a recurring notion is that it could be exploited by developing selective ligands with improved clinical profiles. Here, we comprehensively examined Oprm1 transcriptional variants in the murine central nervous system, using long-read RNAseq as well as spatial and single-cell transcriptomics.