Echinacoside attenuates Klebsiella pneumoniae-induced pneumonia via inhibition of the TLR4/NF-κB signaling.

The Gram-negative bacterium Klebsiella pneumoniae (K. pneumoniae) is one major causative agent of community- and hospital-acquired pneumonia. Echinacoside (ECH) is a phenylethanoid glycoside isolated from Cistanche deserticola that possesses anti-inflammatory activity.

Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer.

Cancer remains a leading cause of mortality globally and a major health burden, with chemotherapy often serving as the primary therapeutic option for patients with advanced-stage disease, partially compensating for the limitations of non-curative treatments. However, the emergence of chemotherapy resistance significantly limits its efficacy, posing a major clinical challenge. Moreover, heterogeneity of resistance mechanisms across cancer types complicates the development of universally effective diagnostic and therapeutic approaches.

New path to green transformation: Exploring the impact of corporate governance on environmental information disclosure quality of new energy companies.

An essential aspect of improving market openness, fostering investor trust, and allowing the establishment and implementation of sustainable development policies lies in enhancing the disclosure quality of new energy firms. This study examines the influence of corporate governance on the disclosure quality of new energy companies listed on the Chinese A-share market. The analysis is conducted using a two-way fixed-effects model and particularly focuses on the role of green transformation in this relationship.

Synergetic degradation of PFOS by HALT conditions enhanced by Fe-based amorphous alloys.

Global concern over per- and polyfluoroalkyl substances (PFASs), especially perfluorooctane sulfonate (PFOS), disposal prompts the search for effective degradation methods. Subcritical water hydrothermal treatment shows promise but suffers from unclear degradation pathways, hindering engineering application design due to unknown intermediate products. This study introduces Fe-based amorphous alloy to enhance the subcritical water hydrothermal degradation of PFOS, achieving a degradation rate of approximately 85 % under optimized conditions of 325 °C and 1 M sodium bicarbonate (NaHCO₃), compared to 56 % without the alloy.