Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial.

Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials compared valproate versus topiramate in patients with migraine showed inconclusive results. We aimed to evaluate the tolerability and efficacy of valproate compared to topiramate in migraineurs from the Middle East and North Africa.

Visual Reliance in Severe Hearing Loss: Visual Evoked Potentials (VEPs) Study.

Unlabelled: Peripheral hearing loss is associated with the cross-modal re-organization of the auditory cortex, which can occur in both pre- and post-lingual deaf cases.

Background/objectives: Whether to rely on the visual cues in cases with severe hearing loss with adequate amplification is a matter of debate. So, this study aims to study visual evoked potentials (VEPs) in children with severe or profound HL, whether fitted with HAs or CIs.

A multicenter trial on the predictors of different subtypes of hemorrhagic infarction after thrombolysis.

Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. Most studies evaluated the post-alteplase haemorrhagic transformation of brain infarction as a homogeneous entity but we evaluated the predictors of each subtype of haemorrhagic transformation of brain infarction.

TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial.

Background: Many studies evaluated the efficacy and safety of ticagrelor versus clopidogrel in patients with ischemic stroke; none of these trials included North African participants, and all of these trials comprised only participants who experienced transient ischemic attack (TIA) or minor stroke.

Objectives: We compared the efficacy and safety of ticagrelor versus clopidogrel in patients with first-ever noncardioembolic moderate or moderate-to-severe ischemic stroke.

Methods: Our trial involved 900 first-ever noncardioembolic patients with acute ischemic stroke (AIS) who randomly received either loading and maintenance doses of ticagrelor or clopidogrel within the first 24 h of stroke onset.