The additive effect between citalopram and muscimol upon induction of antinociceptive effect in male mice.

Previous investigations have revealed the role of GABAergic and serotonergic systems in the modulation of pain behavior. This research aimed to examine the effects of intracerebroventricular (i.c.

Evaluation of RehaCom cognitive rehabilitation on different aspects of visual attention in patients with middle cerebral artery ischemia: A nonblinded randomized clinical trial.

Background: Cerebral ischemia or stroke is the second leading cause of death in the world, and most surviving patients suffer from long-term physical and cognitive disabilities, which create many social and economic problems for them and society. Visual attention impairment is a common cognitive complication among patients with cerebral ischemia, especially in the Middle Cerebral Artery (MCA). One way to improve attention in these patients is cognitive rehabilitation.

Protocol for state-based decoding of hand movement parameters using neural signals.

We present a protocol for decoding kinematic and kinetic parameters from the primary somatosensory cortex during active and passive hand movements in a center-out reaching task using state-based and conventional decoders. We describe steps for preparing data and using the state-based model to classify movement directions into states via feature extraction and predict parameters with regression models (partial least squares and multilinear regression) trained per state. This state-based approach outperforms conventional methods, enhancing accuracy for brain-computer interface applications.

Preclinical evidence for the anxiolytic- and antidepressant-like effects of citicoline and imipramine in the sciatic nerve-ligated mice.

Background: Neuropathic pain is a usual condition followed by nerve injury. Experimental neuropathy is linked with delayed behavioral variations correlated to anxiety and depression behaviors. Imipramine is a tricyclic antidepressant that can diminish anxiety- and depressive-like behaviors.

Synergistic interaction between clonidine and ACPA on the modulation of anxiety-like behaviors in non-acute restraint stress and acute restraint stress conditions.

The present research examined the possible role of α-2 adrenergic receptor drugs (clonidine, selective α-2 adrenergic receptor agonist, and yohimbine, competitive α-2 adrenoreceptor antagonist,) on the effect of arachidonylcyclopropylamide (ACPA), a cannabinoid CB1 receptor agonist, in non-acute restraint stress (NARS) and acute restraint stress (ARS) mice. The animals were unilaterally implanted with a cannula in the left lateral ventricle. ARS was carried out by movement restraint at a period of 4 h.