Publications by authors named "M Zalecki"
Article Synopsis
- Diabetic peripheral neuropathy (DPN) is linked to disruptions in the RAGE-Diaph1 signaling pathway, affecting both peripheral nerves and the spinal cord.
- In type 1 diabetes, significant molecular changes were found in the spinal cord, with over 500 differentially expressed genes, highlighting the PI3K-Akt pathway as most affected.
- Cathepsin E emerges as a potential key target for treating DPN, with limited overlap in gene changes between the sciatic nerve and spinal cord in diabetic mice.
The aim of this study was to determine the applicability of commonly used dyes (CWS and CFB) to stain different types of β-glucans in water and selected, most popular, dairy products for CLSM imaging analysis. Structurally different pure β-glucan preparations: curdlan-CU, oat β-glucan-OG and scleroglucan-SC were tested. Our study showed for the first time that CWS is a dye with a specific affinity for all analyzed β-glucans, while CFB is suitable for curdlan labeling only.
View Article and Find Full Text PDFArticle Synopsis
- The review examines the role of RAGE (receptor for advanced glycation end-products) in the nervous system, highlighting recent findings on its interactions and signaling pathways.
- Despite significant research progress, translating these discoveries into effective clinical treatments has been challenging due to an incomplete understanding of RAGE's functions.
- Clinical trials attempting to block RAGE interactions have not yielded promising results, but new trials with alternative blocking agents are still underway, offering hope for future therapeutic applications in neurological diseases.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive degeneration of upper and lower motor neurons that causes paralysis and muscle atrophy. The pathogenesis of the disease is still not elucidated. Receptor for Advanced Glycation End Product (RAGE) is a major component of the innate immune system and has implications in ALS pathogenesis.
View Article and Find Full Text PDFCocaine- and amphetamine-regulated transcript (CART) is a peptide suggested to play a role in gastrointestinal tract tissue reaction to pathology. Gastric ulceration is a common disorder affecting huge number of people, and additionally, it contributes to the loss of pig livestock production. Importantly, ulceration as a focal disruption affecting deeper layers of the stomach wall differs from other gastrointestinal pathologies and should be studied individually.
View Article and Find Full Text PDF