The Role of the JAK-STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia.

B-cell lymphoblastic leukemia is a hematologic neoplasm that poses a serious health concern in childhood. Genetic aberrations, such as mutations in the genes , , and or gene fusions involving ::, ::, and ::, often correlate with the onset of this disease. These aberrations can lead to malfunction of the JAK-STAT signaling pathway, which is implicated in various important biological processes, including those related to immunology.

Sarcasm use in Turkish: The roles of personality, age, gender, and self-esteem.

This study examined how self-reported sarcasm use is related to individual differences in non-Western adults. A sample of 329 Turkish speakers of high socioeconomic status completed an online survey including measures of self-reported sarcasm use, personality traits, positive and negative affect, self-presentation styles, self-esteem, as well as age and gender. Participants who reported being more likely to use sarcasm in social situations had scores indicating that they were less agreeable, less conscientious, and less emotional stable (i.

LATS1 Is a Mediator of Melanogenesis in Response to Oxidative Stress and Regulator of Melanoma Growth.

The LATS1 kinase has been described as a tumor suppressor in various cancers. However, its role in melanoma has not been fully elucidated. There are several processes involved in tumorigenesis, including melanin production.

Polymorphism and expression of the Dvl3 gene in the etiology of depressive disorder.

Objectives: The aim of this study was to investigate the role of the Dvl3 gene in the etiology of depression by comparison of Dvl3 mRNA expression, Dvl3 protein levels and polymorphism at locus rs1969253 located in the intron of the Dvl3 gene in patients suffering from depression versus healthy controls, as well as to search for clinical variables related to polymorphism or expression of the analyzed gene.

Methods: Study group involved 181 individuals suffering from recurrent depressive disorder or depressive episode. Control group consisted of 102 healthy individuals.

"Sure I'll help-I've just been sitting around doing nothing at school all day": Cognitive flexibility and child irony interpretation.

Successful peer relations in older children depend on proficiency with banter, which in turn frequently involves verbal irony. Individual differences in successful irony interpretation have traditionally been attributed to theory of mind. Our premise was that the key factor might in fact be cognitive flexibility, that is, the ability to switch between different perspectives (here, on the same utterance).