Publications by authors named "M Zain Khakwani"
Article Synopsis
- * Only the right eye of the patient received treatment due to financial limitations, yet both eyes showed significant visual improvement within weeks, suggesting the potential benefits of this effect.
- * The findings point to the need for further research on anti-VEGF therapies, personalized treatment plans, and highlight the urgency of accessible AMD treatments in developing countries, especially after recent treatment restrictions in Pakistan.
Background: Nuclear pore complexes (NPCs) are the architectures entrenched in nuclear envelop of a cell that regulate the nucleo-cytoplasmic transportation of materials, such as proteins and RNAs for proper functioning of a cell. The appropriate localization of proteins and RNAs within the cell is essential for its normal functionality. For such a complex transportation of materials across the NPC, around 60 proteins are involved comprising nucleoporins, karyopherins and RAN system proteins that play a vital role in NPC's structure formation, cargo translocation across NPC, and cargoes' rapid directed transportation respectively.
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- Pakistan has experienced multiple HIV outbreaks over the past 20 years, with a surge in cases since 2018, particularly among high-risk groups like drug users, men who have sex with men, and sex workers.
- Key factors contributing to the rise in HIV infections include poor infection control, unsafe blood transfusions, unethical healthcare practices, and a lack of public awareness, combined with insufficiently trained healthcare providers.
- Sustainable solutions require comprehensive efforts from all stakeholders to improve testing, tracing, and treatment, while also addressing the root causes of these outbreaks that have been neglected so far.
Article Synopsis
- Pakistan has experienced multiple HIV outbreaks over the last two decades, particularly centered in Larkana, which has seen alarming cases shift from high-risk groups to a low-risk pediatric population in 2019.
- This shift raises concerns about the increasing spread of HIV into the general public and suggests that control strategies are not effectively managing the epidemic, leading to a rise in overall cases.
- The review aims to summarize known risk factors from past outbreaks, investigate potential connections like child sexual abuse in recent cases, and propose strategies to combat future HIV outbreaks in Pakistan.