Publications by authors named "M Zahi"

Article Synopsis
  • Curcumin, a yellow pigment known for its anti-inflammatory and antioxidant properties, has been associated with various health benefits for diseases like diabetes, cancer, and more.
  • Despite its benefits, curcumin faces challenges such as low bioavailability and degradation under certain conditions, prompting research into micro-encapsulation techniques to enhance its stability and solubility.
  • This review explores different shell materials and methods for microencapsulating curcumin, along with its applications in food, medicine, and cosmetics, while also discussing recent research findings and future challenges in the field.
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The Mediterranean olive oil industries are producing annually a massive quantity of olive mill wastewater (OMWW). Unfortunately, the OMWW is released arbitrarily in the nature without any pretreatment. Thus, it exhibits a high toxicity against the whole natural ecosystem including, microorganisms, plants and animals.

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Article Synopsis
  • The study evaluates the outcomes of sphincter-sparing techniques combined with total mesorectal excision (TME) for treating anorectal adenocarcinoma, involving 93 patients over five years.
  • The methods included various surgical approaches such as intersphincteric resection and assessed anal function one year post-surgery using the Per Anal Examination Scoring System (PASS).
  • Results showed that while about 10.6% of patients experienced fecal incontinence, most retained normal anal tone, indicating that sphincter preservation is effective in avoiding permanent stomas and maintaining reasonable function.
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Previously, we focused on a series of 2-aminobenzamide-based histone deacetylase (HDAC) inhibitors, compound 9 of which displayed potent HDAC inhibitory activity against HDAC1 and HDAC2, and moderate anti-proliferative activity against several cancer cell lines. In the current study, we have designed and synthesized a series of novel HDAC inhibitors based on thioether moiety with 9 as a lead compound. Representative compounds12 g and 12 h showed apparently potent anti-proliferative activities against five solid cancer cell lines: A549, HCT116, Hela, A375 and SMMC7721, and low cytotoxicity against NIH 3T3 normal cells.

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An effective antimicrobial system was developed by using oregano essential oil (OEO) Pickering emulsion. The Pickering emulsion was stabilized by cellulose nanocrystals (CNCs), which were from microcrystalline cellulose (MCC) by selective oxidization ammonium persulfate. Factors affecting the stability of OEO Pickering emulsions, such as oil/water ratio, CNCs concentration, ionic concentration and pH, were studied and analysed by the measurement of the droplet sizes and Zeta potential.

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