Publications by authors named "M Zafeiri"
Background: The polygenic nature of autism spectrum disorder (ASD) requires the identification of converging genetic pathways during early development to elucidate its complexity and varied manifestations.
Methods: We developed a human cerebral organoid model from induced pluripotent stem cells with targeted genome editing to abolish protein expression of the ASD risk gene.
Results: CNTNAP2 cerebral organoids displayed accelerated cell cycle, ventricular zone disorganization, and increased cortical folding.
Article Synopsis
- Acute myocarditis involves inflammation of the heart muscle that can be triggered by infections or non-infectious factors, leading to a wide range of symptoms from mild discomfort to severe heart failure needing urgent care.
- This condition's development is influenced by both the triggering factors and the body's immune response, with common causes including viruses, autoimmune reactions, and certain medications.
- Diagnosing myocarditis is challenging due to its varied symptoms; thus, a thorough approach using clinical evaluations, imaging, and biopsies is necessary, while management typically focuses on supportive care with limited specific treatments.
Background: The newly developed COVID-19 vaccines are highly effective and safe. However, a small portion of vaccine recipients experience a wide range of adverse events. Recently, glomerular disease, including the development of Minimal Change Disease (MCD), has been observed after administration of different COVID-19 vaccines, although causality remains a matter of debate.
View Article and Find Full Text PDFAims: To provide an overview of reported cases of new-onset type 1 diabetes mellitus (T1D) following COVID-19 infection.
Methods: PubMed and Scopus library databases were screened for relevant case reports published between January 2020 and June 2022. Study design, geographic region or language were not restricted.