Publications by M Zabari

Publications by authors named "M Zabari"

Sci Transl Med

February 2022

Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disease with a significant genetic component, and changes in DNA methylation can provide insights into its progression and risk factors.* -
A large study analyzed blood samples from nearly 10,000 individuals, identifying 45 specific DNA methylation changes linked to 42 genes, which are involved in metabolism, cholesterol production, and immune response.* -
The research found that lifestyle factors like cholesterol levels, body mass index, and alcohol consumption are independently linked to ALS, and certain DNA methylation patterns could help predict patient survival and guide future treatments.*

Nat Genet

March 2022

Nat Genet

December 2021

ALS is a life-threatening neurodegenerative disease affecting 1 in 350 individuals, and there is a significant need for treatments that modify the disease's progression.
A large genome-wide association study (GWAS) identified 15 genetic risk loci associated with ALS by analyzing data from nearly 30,000 ALS patients compared to over 122,000 controls.
The study highlights genetic connections to other neurodegenerative traits and concludes that high cholesterol levels may play a causal role in ALS, emphasizing disturbances in cellular transport and autophagy as key factors in the disease’s development in glutamatergic neurons.

Meat Sci

September 2020

Nature

August 2019

ALS is a complex neurodegenerative disorder influenced by both genetic and environmental factors, showing different symptoms based on individual circumstances.
Research on Sod1 transgenic mice indicates that changes in gut bacteria (dysbiosis) and metabolites can affect the severity of ALS, with specific bacteria like Akkermansia muciniphila improving symptoms while others worsen them.
A preliminary study in humans shows similar differences in microbiome and metabolite levels between ALS patients and healthy individuals, suggesting that gut-brain interactions may play a role in ALS, warranting further research.