Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of (Wight.)'s Leaf Extract in Streptozotocin-Induced Diabetic Rat Model.

(1) Background: An earlier study on the hypoglycemic activity of S. polyanthum (Wight.) leaf methanol extract identified squalene as the major chemical compound.

The Adipokine Component in the Molecular Regulation of Cancer Cell Survival, Proliferation and Metastasis.

A hormonal imbalance may disrupt the rigorously monitored cellular microenvironment by hampering the natural homeostatic mechanisms. The most common example of such hormonal glitch could be seen in obesity where the uprise in adipokine levels is in virtue of the expanding bulk of adipose tissue. Such aberrant endocrine signaling disrupts the regulation of cellular fate, rendering the cells to live in a tumor supportive microenvironment.

Vasorelaxant effect of water fraction of and its mechanisms in spontaneously hypertensive rats aortic ring preparation.

Introduction: has been reported to possess activities including antioxidant, anti-aging and anti-cancer but there is no report on its vasorelaxant effects.

Objective: This study aims to fractionate water extract of , identify the compound(s) involved and elucidate the possible mechanism(s) of its vasorelaxant effects.

Methods: Water extract of was subjected to liquid-liquid extraction to obtain ethyl acetate, n-butanol and water fractions.

Antihypertensive activity and vascular reactivity mechanisms of leaf extracts in spontaneously hypertensive rats.

Background: has been used traditionally in hypertension treatment but not yet scientifically assessed. The objective of the study is to investigate the antihypertensive and vasorelaxant activities of , study its underlying pharmacological mechanisms, and identify the relevant vasoactive compounds.

Methods: Successive extractions of leaf were carried out to produce petroleum ether (VPPE), chloroform (VPCE), methanol (VPME), and water (VPWE) extracts.

Lam. leaf extracts reverse metabolic syndrome in Sprague Dawley rats fed high-fructose high fat diet for 60-days.

Lam. has been used traditionally for the treatment of different cardio-metabolic disorders. So, the aim was to assess its leaf extracts in metabolic syndrome rat model.