Publications by authors named "M Z Schubert"
Hip abductors are essential for hip function. To understand abduction weakness, it is important to know which muscles contribute to abduction force. Our aim was to investigate the effects of an experimentally induced weakness of the different muscles (tensor fasciae latae [TFL], gluteus medius and minimus (Gmed/min), gluteus maximus [Gmax]) on the abduction force.
View Article and Find Full Text PDFBackground: Dementia is a progressive and terminal illness. Symptoms are present for people with dementia across all stages, leading to poor quality of life and considerable carer burden. In acute and community care services, no holistic, person-centred outcome tools are available for nurses and informal caregivers to measure symptoms and needs from the person`s with dementia point of view.
View Article and Find Full Text PDFBackground: Magnetic resonance imaging may suggest spinal cord compression and structural lesions in degenerative cervical myelopathy (DCM) but cannot reveal functional impairments in spinal pathways. We aimed to assess the value of contact heat evoked potentials (CHEPs) in addition to MRI and hypothesized that abnormal CHEPs may be evident in DCM independent of MR-lesions and are related to dynamic mechanical cord stress.
Methods: Individuals with DCM underwent neurologic examination including segmental sensory (pinprick, light touch) and motor testing.
Background: Spinal cord injury results in permanent neurological impairment and disability due to the absence of spontaneous regeneration. NG101, a recombinant human antibody, neutralises the neurite growth-inhibiting protein Nogo-A, promoting neural repair and motor recovery in animal models of spinal cord injury. We aimed to evaluate the efficacy of intrathecal NG101 on recovery in patients with acute cervical traumatic spinal cord injury.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastomas are aggressive brain tumors that resist treatment and utilize neuron-tumor connections to promote their growth, with cholinergic neurons playing a key role in this invasion.
- The study utilized rabies viruses for retrograde tracing to reveal how glioblastomas integrate into brain circuits, showing that radiotherapy can enhance neuron-tumor connectivity, complicating treatment efforts.
- By disrupting neuron-tumor connections, researchers discovered a potential therapeutic approach that could halt glioblastoma progression, emphasizing the need to target these synapses for better treatment outcomes.