Challenges and support needs among family caregivers involved in solid organ transplant care process: a scoping review protocol.

Introduction: Family caregivers play an indispensable role in the care of solid organ transplant patients, undertaking a wide range of tasks from basic daily care to complex medical management. However, these responsibilities come with substantial challenges, placing additional strain on caregivers who bear significant physical, emotional, financial and social burdens, along with numerous unmet support needs. Currently, the exploration of challenges and support needs among family caregivers in the caregiving process is limited to primary research, lacking a synthesised and comprehensive understanding of the issues.

PKR modulates sterile systemic inflammation-triggered neuroinflammation and brain glucose metabolism disturbances.

Sterile systemic inflammation may contribute to neuroinflammation and accelerate the progression of neurodegenerative diseases. The double-stranded RNA-dependent protein kinase (PKR) is a key signaling molecule that regulates immune responses by regulating macrophage activation, various inflammatory pathways, and inflammasome formation. This study aims to study the role of PKR in regulating sterile systemic inflammation-triggered neuroinflammation and cognitive dysfunctions.

[Urge urinary incontinence in women between 40 and 65 years: prevalence, quality of life, social impact, and costs].

Background: urge urinary incontinence (UUI) is the involuntary loss of urine accompanied or immediately preceded by a sudden and strong desire to urinate that cannot be delayed or that is difficult to postpone. Data claim that UUI increases significantly from 40 to 65 years, which is why this specific age group, which has been little studied in the literature, deserves to be investigated. Moreover, they are socially active and working women who represent a social and economic resource for the country: therefore, their malaise is not only a personal problem, but also a problem for the society.

Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology.

L, an important ornamental, economic, and medicinal plant, is renowned for producing paclitaxel (Taxol®), a potent chemotherapeutic agent. The biosynthesis of paclitaxel involves intricate biosynthetic pathways, spanning multiple enzymatic steps. Despite advances, challenges remain in optimizing production methods.

Diagnostic value of deep learning of multimodal imaging of thyroid for TI-RADS category 3-5 classification.

Background: Thyroid nodules classified within the Thyroid Imaging Reporting and Data Systems (TI-RADS) category 3-5 are typically regarded as having varying degrees of malignancy risk, with the risk increasing from TI-RADS 3 to TI-RADS 5. While some of these nodules may undergo fine-needle aspiration (FNA) biopsy to assess their nature, this procedure carries a risk of false negatives and inherent complications. To avoid the need for unnecessary biopsy examination, we explored a method for distinguishing the benign and malignant characteristics of thyroid TI-RADS 3-5 nodules based on deep-learning ultrasound images combined with computed tomography (CT).