Publications by authors named "M Z Ladjemi"
Clinical observations suggest that the source of primary infection accounts for a major determinant of further nosocomial pneumonia in critically ill patients with sepsis. Here we addressed the impact of primary nonpulmonary or pulmonary septic insults on lung immunity using relevant double-hit animal models. C57BL/6J mice were first subjected to polymicrobial peritonitis induced by cecal ligation and puncture (CLP) or bacterial pneumonia induced by intratracheal challenge with .
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- Cystic fibrosis (CF) causes lung problems due to bacteria and inflammation, leading to worse health during flare-ups.
- Researchers studied different types of immune cells called neutrophils in people with CF under stable conditions and during flare-ups, comparing them to healthy people.
- They found that during flare-ups, neutrophils from CF patients showed more signs of being active and that some specific neutrophils increased, which could help explain why patients get sicker.
Article Synopsis
- - The study investigates the immune response in 15 COVID-19 patients with pneumonia by using single-cell RNA-sequencing to analyze blood antigen-presenting cells (APCs) and compare them to 4 healthy donors.
- - It finds multiple immune system deficiencies in severe cases, including increased cell death in key immune cells, reduced innate sensors, and downregulated genes critical for antiviral defense and antigen presentation.
- - These insights could help explain why some patients worsen and provide potential strategies to enhance their immune responses against the virus.
Background: Phenotypes and endotypes predicting optimal response to bronchial thermoplasty (BT) in patients with severe asthma remain elusive.
Objective: Our aim was to compare the clinical characteristics and hallmarks of airway inflammation and remodeling before and after BT in responder and partial responder patients with severe asthma refractory to oral steroids and to omalizumab.
Methods: In all, 23 patients with severe refractory asthma were divided into BT responders (n = 15) and BT partial responders (n = 8), according to the decrease in asthma exacerbations at 12 months after BT.
Background: Tertiary lymphoid structures (TLS) are triggered by persistent bronchopulmonary infection with , but their roles remain elusive. The present study sought to examine the effects of B- and/or T-cell depletion on infection and TLS development (lymphoid neogenesis) in mice.
Methods: C57Bl/6 mice were pre-treated with 1) an anti-CD20 monoclonal antibody (mAb) (B-cell depletion) or 2) an anti-CD4 and/or an anti-CD8 mAb (T-cell depletion) or 3) a combination of anti-CD20, anti-CD4 and anti-CD8 mAbs (combined B- and T-cell depletion) or 4) isotype control mAbs.