Factors associated with survival following allogeneic transplantation for myeloid neoplasms harboring TP53 mutations.

Allogeneic stem cell transplant (alloHCT) is considered for all patients with myeloid neoplasms (MN) harboring TP53-mutations (TP53mut). The aim of this international study across 7 transplant centers in USA and Australia was to identify factors associated with improved post-alloHCT survival. Of 134 TP53mut MN cases who underwent alloHCT, 80% harbored complex karyotype (CK); 94% of TP53 variants were localized to the DNA-binding domain (DBD).

Thiram-induced ER stress promotes mitochondrial calcium signaling and NLRP3 inflammasome activation in a tissue specific manner.

Thiram, a broadly used dithiocarbamate fungicide, exaggerates endoplasmic reticulum (ER) stress and interferes with mitochondrial function, thus disrupting cellular homeostasis. Here, we intend to identify the molecular actions of thiram at the mitochondrial-associated ER membranes (MAMs) that lead to the induction of ER stress and mitochondrial calcium overload in both liver and bone tissues. Taken together, we show that thiram-induced remodelling of MAMs leads to huge ER stress and calcium dysregulation.

Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.

Background: Despite the close association of Alzheimer's disease (AD) with muscle decline, the biomarkers of age-related muscle loss, termed sarcopenia, in AD remain elusive.

Objectives: We investigated the plasma neurofilament light (NfL) chain levels as potential biomarkers of sarcopenia in AD patients. DESIGN SETTING, PARTICIPANTS, MEASUREMENTS: We conducted a cross-sectional, observational study on older adults, including controls and patients with AD (n = 38-44/group).

Lightweight-CancerNet: a deep learning approach for brain tumor detection.

Detecting brain tumors in medical imaging is challenging, requiring precise and rapid diagnosis. Deep learning techniques have shown encouraging results in this field. However, current models require significant computer resources and are computationally demanding.

Structurally modified carbon nanotubes as twisted fibers towards electrochemical detection of environmentally hazardous cartap.

Pesticides such as cartap play a crucial role in agriculture, as they are extensively used in controlling pests in crops like sugarcane, rice and vegetables. However, their excessive usage poses major threats to human health, causing neurotoxicity and respiratory disorders. In addition, they harm aquatic ecosystems by disrupting biodiversity.