Publications by authors named "M Yule"
Article Synopsis
- This study investigates the effectiveness of single-slice versus multi-slice computed tomography (CT) methods in analyzing body composition in patients with oesophagogastric cancer, focusing on their correlation and impact on survival rates.
- Researchers examined CT scans of 504 patients, comparing measurements of skeletal muscle, subcutaneous, visceral, and intermuscular adipose tissue, finding high correlation and narrow limits of agreement between the two methods.
- Results indicate that both measurement techniques offer similar insights into body composition, suggesting that the clinical use of multi-slice analyses may be beneficial but requires further exploration for optimal application.
Background & Aims: Malnutrition is highly prevalent in those with cancer and more so in those with incurable cancer. In incurable cancer, it is widely agreed that optimal nutritional care has the potential to positively impact patient and caregiver distress and oncological outcomes. The aim of this systematic review was to describe the diversity and frequency of nutritional interventions, whether given in isolation or as part of a multimodal intervention in those with incurable cancer, in randomised controlled trials.
View Article and Find Full Text PDFRegulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently.
View Article and Find Full Text PDFPurpose Of Review: Cachexia is a devasting syndrome which impacts a large number of patients with cancer. This review aims to provide a comprehensive overview of the central mechanisms of cancer cachexia. In particular, it focuses on the role of the central nervous system (CNS), the melanocortin system, circulating hormones and molecules which are produced by and act on the CNS and the psychological symptoms of cancer cachexia.
View Article and Find Full Text PDF