Publications by authors named "M Yuksel"
Background: BIN1, the second strongest GWAS risk factor for late-onset Alzheimer's disease (AD), encodes a nucleocytoplasmic adaptor protein that plays many roles in multiple tissue and cell types. It is known that BIN1 can directly bind to tau in vitro, and neuronal BIN1 expression decreases in patients with AD. Accumulation of intracellular hyperphosphorylated tau is a hallmark pathogenic feature of AD and related tauopathies.
View Article and Find Full Text PDFBackground: The study evaluated the relationship between balance function and skeletal muscle mass index (ASMI), physical function, and fatigue in children with chronic kidney disease (CKD).
Methods: A cross-sectional study of 83 children with CKD (stages 1-4, dialysis, transplant) and 71 healthy controls was conducted. Functional performance tests, including gait speed, 6-min walk distance (6MWD), five-repetition sit-to-stand (5RST), and timed up-and-go (TUG) tests, were administered.
Article Synopsis
- Despite progress in ulcer treatment, there’s a continuous need for new, effective ways to prevent and treat ulcers.
- This study tested the effects of krill oil, fish oil, and astaxanthin on rats with ethanol-induced gastric ulcers by comparing biochemical and histological data after 4 weeks of supplementation.
- Results showed that while both krill and fish oil provided protective benefits, astaxanthin offered the most significant protection by reducing harmful substances and inflammation linked to ulcer damage.
Article Synopsis
- - Testicular ischemia reperfusion (I/R) injury poses a major issue in urology, and the study investigates the protective effects of the antioxidant -Anethole on this condition in male rats.
- - Twenty-eight rats were divided into four groups, with two groups receiving 100 or 200 mg/kg -Anethole during ischemia; results showed significant improvements in the I/R + 200 group compared to the I/R group, particularly in reducing oxidative stress and inflammation.
- - The findings suggest that -Anethole may offer gonadoprotective benefits during testicular I/R injury, specifically by influencing the transcription factors STAT3 and NF-κB, but further evaluation of potential benefits and side effects
Article Synopsis
- The study aimed to examine how the pharmacokinetics of marbofloxacin varies with the age of calves after a single IV dose of 10 mg/kg.
- It involved Montofon calves of different ages (1, 2, and 4 months), measuring plasma concentrations and calculating pharmacokinetic parameters like half-life, volume of distribution, total clearance, and area under the curve (AUC) using HPLC.
- Findings indicated that as calves age, the elimination half-life and AUC decrease while total clearance increases, suggesting that the effectiveness of marbofloxacin may decline with age, calling for a reevaluation of the dosing strategy based on the bacteria's minimum inhibitory concentration (MIC) values.