Publications by authors named "M Yu Pakharukova"
Background: Epidemiologically important food-borne trematodes Opisthorchis viverrini and Clonorchis sinensis are recognized as biological carcinogens of Group 1A, while Opisthorchis felineus is in Group 3 as noncarcinogenic to humans. Mechanisms of the biological carcinogenesis are still elusive. Some studies highlight chronic inflammation as a key factor and common pathway for cancer initiation and progression.
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- * In hamster models, researchers found that liver damage varied by species, with O. viverrini linked to a specific type of cancer and O. felineus and C. sinensis causing similar liver fibrosis.
- * A significant correlation was identified between liver and kidney damage, suggesting a connection in the disease progression caused by these parasites. Future research is encouraged to understand serious complications and the role of other factors in liver fluke-related carcinogenesis
Chronic nonhealing wounds, such as diabetic ulcers, are among the most serious complications of diabetes mellitus. Consequently, the search for new therapeutic strategies remains highly relevant. Based on our previous data on acute wounds, bioactive molecules derived from the liver fluke hold promise as a novel approach to wound healing.
View Article and Find Full Text PDFCarcinogenic food-borne liver fluke infections are a serious epidemiological threat worldwide. The major complications of infection are chronic inflammation and biliary intraepithelial neoplasia. Although evidence has accumulated that increased reactive oxygen species production is observed in liver fluke infection, a direct relationship between the oxidative stress and biliary intraepithelial neoplasia has not been shown.
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- The liver fluke Opisthorchis felineus is a foodborne pathogen primarily found in Russia, Kazakhstan, and parts of Europe, which can lead to liver complications such as fibrosis in infected mammals and humans.
- Research is focusing on how the fluke's presence triggers pathological changes, particularly examining the role of neoangiogenesis (formation of new blood vessels) and amyloid deposits in liver tissues of infected individuals.
- The study demonstrated that there is a significant increase in these new vessels and amyloid deposits in patients with chronic opisthorchiasis, suggesting that angiogenesis may play a key role in worsening liver fibrosis linked to the infection.