Publications by authors named "M Yokode"
Background: Pouchitis is the most common complication of restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We previously reported the presence of anti-integrin αvβ6 antibodies in the serum of patients with UC. This study investigated the association between anti-integrin αvβ6 antibodies and the development of pouchitis in patients with UC.
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- The study aimed to validate anti-integrin αvβ6 autoantibodies as a diagnostic biomarker for primary sclerosing cholangitis (PSC) using a new ELISA Kit across multiple hospitals.
- The research involved 81 PSC patients and 358 controls, finding a strong correlation between two testing methods and demonstrating high sensitivity (82.7%) and specificity (94.4%) for diagnosing PSC.
- The presence of these autoantibodies was particularly pronounced in PSC patients without inflammatory bowel disease, highlighting their potential as a reliable biomarker for PSC.
Article Synopsis
- The use of immune checkpoint inhibitors (ICIs) has led to increased incidents of ICI-induced liver injury, making it a significant concern for healthcare providers. !* -
- Severe liver injuries often require corticosteroid treatment, necessitating thorough evaluations including clinical assessments, blood tests, imaging, and sometimes liver biopsies for accurate diagnosis. !* -
- Distinguishing between types of liver injury, such as acute hepatitis-like effects and cholangitis, is crucial for effective treatment, with non-hepatocellular injuries often responding poorly to corticosteroids, highlighting the need for interdisciplinary cooperation in diagnosis and management. !*