Publications by authors named "M Yasuda-Yamahara"
For the advancement of DKD treatment, identifying unrecognized residual risk factors is essential. We explored the impact of obesity diversity derived from different carbohydrate qualities, with an emphasis on the increasing trend of excessive fructose consumption and its effect on DKD progression. In this study, we utilized db/db mice to establish a novel diabetic model characterized by fructose overconsumption, aiming to uncover the underlying mechanisms of renal damage.
View Article and Find Full Text PDFThe prevalence of chronic kidney disease (CKD) is increasing worldwide, making the disease an urgent clinical challenge. Caloric restriction has various anti-aging and organ-protective effects, and unraveling its molecular mechanisms may provide insight into the pathophysiology of CKD. In response to changes in nutritional status, intracellular nutrient signaling pathways show adaptive changes.
View Article and Find Full Text PDFArticle Synopsis
- The discovery of insulin around a century ago significantly improved diabetes management and reduced life-threatening complications like ketoacidosis, greatly benefiting patient health.
- There's a lingering negativity towards ketone bodies due to their association with ketoacidosis, even though they were once valued as crucial energy sources during fasting and exercise.
- Recent research is shifting perspectives on ketone bodies, exploring their potential roles in promoting longevity and their effects on various organs, including the heart, kidneys, muscles, and brain, as well as potential implications for cancer.
Article Synopsis
- * There is increasing research indicating that ketone bodies may provide health benefits, particularly in protecting organs as we age and potentially preventing kidney diseases, including diabetic kidney disease (DKD).
- * While more research is needed, emerging evidence suggests that ketone bodies can ease kidney stress from high sugar levels, reduce inflammation, and slow the progression of kidney diseases.
Renal artery stenosis-induced chronic renal ischemia is an important cause of renal dysfunction, especially in older adults, and its incidence is currently increasing. To elucidate the mechanisms underlying chronic renal hypoperfusion-induced kidney damage, we developed a novel mouse model of renal artery coiling-based chronic hypoperfusion-related kidney injury. This model exhibits decreased renal blood flow and function, atrophy, and parenchymal injury in the coiled kidney, along with compensatory hypertrophy in the non-coiled kidney, without chronic hypertension.
View Article and Find Full Text PDF